Network Approaches to the Mechanical Failure of Soft Tissues: Implications for Disease and Tissue Engineering View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2016

AUTHORS

Béla Suki , Arnab Majumdar

ABSTRACT

Damage and mechanical failure of soft tissues can lead to diseases and even life threatening conditions including the failure of prosthetic heart valves, capillary stress failure, tissue destruction in pulmonary emphysema, and vessel wall aneurysms. Microscale damage occurs when mechanical forces in the tissue are sufficiently high to rupture intercellular connections or enzymatically weakened extracellular matrix (ECM) elements. When the microscale damage reaches a critical amount, tissue or organ failure can happen. In this chapter, we first briefly review the failure of the main constituents of tissues including molecules, cells, elastin, collagen, and proteoglycans. We then discuss failure of tissues modeled as complex networks of these constituents. A key concept here is percolation, a process where network elements reach from one boundary of the network to another. We show that when a certain type of fiber percolates the tissue, the rupture process of the network is primarily governed by the failure properties of the individual fibers. When the main fiber component does not percolate, the failure stress is still dominated by the stiffness of the fiber, but the failure strain emerges as a network phenomenon. Finally, we conclude by proposing some general concepts of how to potentially minimize the risk of failure and best repair a damaged network. More... »

PAGES

417-437

Book

TITLE

Structure-Based Mechanics of Tissues and Organs

ISBN

978-1-4899-7629-1
978-1-4899-7630-7

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4899-7630-7_21

DOI

http://dx.doi.org/10.1007/978-1-4899-7630-7_21

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030405059


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