UV-Induced Immunosuppression View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1993

AUTHORS

Frances P. Noonan , Edward C. De Fabo

ABSTRACT

In mammals, ultraviolet-B radiation impacts on the skin and on the eyes (Zigman, Chapter 6 this volume). Because of effective absorption by skin components, very little of the incident UV-B penetrates beyond the epidermis. In spite of this, UV-B radiation is intimately linked with the mammalian immune system. In this chapter, we will describe a specific immunosuppression initiated by UV-B and discuss the mechanism of its generation. UV-B-induced immunosuppression may be a fundamental biological regulatory mechanism, designed to protect against autoimmune attack on sunlight-altered skin, the adverse effect of which is to permit the outgrowth of UV-induced skin cancers. In addition to this specific immunosuppression, irradiation with UV-B also releases a number of cytokines and induces the expression on keratinocytes of cell-surface immunologic receptors, which may be of significance in UV-related dermatologie disorders. More... »

PAGES

113-148

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4899-2406-3_5

DOI

http://dx.doi.org/10.1007/978-1-4899-2406-3_5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030115617


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Laboratory of Photoimmunology and Photobiology, Department of Dermatology, The George Washington University Medical Center, 20037, Washington, DC, USA", 
          "id": "http://www.grid.ac/institutes/grid.411841.9", 
          "name": [
            "Laboratory of Photoimmunology and Photobiology, Department of Dermatology, The George Washington University Medical Center, 20037, Washington, DC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Noonan", 
        "givenName": "Frances P.", 
        "id": "sg:person.01004530501.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004530501.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Photoimmunology and Photobiology, Department of Dermatology, The George Washington University Medical Center, 20037, Washington, DC, USA", 
          "id": "http://www.grid.ac/institutes/grid.411841.9", 
          "name": [
            "Laboratory of Photoimmunology and Photobiology, Department of Dermatology, The George Washington University Medical Center, 20037, Washington, DC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Fabo", 
        "givenName": "Edward C.", 
        "id": "sg:person.074635015.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.074635015.51"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1993", 
    "datePublishedReg": "1993-01-01", 
    "description": "In mammals, ultraviolet-B radiation impacts on the skin and on the eyes (Zigman, Chapter 6 this volume). Because of effective absorption by skin components, very little of the incident UV-B penetrates beyond the epidermis. In spite of this, UV-B radiation is intimately linked with the mammalian immune system. In this chapter, we will describe a specific immunosuppression initiated by UV-B and discuss the mechanism of its generation. UV-B-induced immunosuppression may be a fundamental biological regulatory mechanism, designed to protect against autoimmune attack on sunlight-altered skin, the adverse effect of which is to permit the outgrowth of UV-induced skin cancers. In addition to this specific immunosuppression, irradiation with UV-B also releases a number of cytokines and induces the expression on keratinocytes of cell-surface immunologic receptors, which may be of significance in UV-related dermatologie disorders.", 
    "editor": [
      {
        "familyName": "Young", 
        "givenName": "Antony R.", 
        "type": "Person"
      }, 
      {
        "familyName": "Moan", 
        "givenName": "Johan", 
        "type": "Person"
      }, 
      {
        "familyName": "Bj\u00f6rn", 
        "givenName": "Lars Olof", 
        "type": "Person"
      }, 
      {
        "familyName": "Nultsch", 
        "givenName": "Wilhelm", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-1-4899-2406-3_5", 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-1-4899-2408-7", 
        "978-1-4899-2406-3"
      ], 
      "name": "Environmental UV Photobiology", 
      "type": "Book"
    }, 
    "keywords": [
      "specific immunosuppression", 
      "UV-induced skin cancer", 
      "UV-Induced Immunosuppression", 
      "number of cytokines", 
      "autoimmune attack", 
      "mammalian immune system", 
      "immunosuppression", 
      "skin cancer", 
      "immune system", 
      "adverse effects", 
      "skin components", 
      "skin", 
      "regulatory mechanisms", 
      "cytokines", 
      "cancer", 
      "receptors", 
      "disorders", 
      "keratinocytes", 
      "eyes", 
      "epidermis", 
      "outgrowth", 
      "expression", 
      "mechanism", 
      "significance", 
      "effect", 
      "mammals", 
      "spite", 
      "addition", 
      "number", 
      "impact", 
      "incidents", 
      "irradiation", 
      "biological regulatory mechanisms", 
      "attacks", 
      "components", 
      "absorption", 
      "effective absorption", 
      "chapter", 
      "system", 
      "generation", 
      "UV", 
      "radiation impact"
    ], 
    "name": "UV-Induced Immunosuppression", 
    "pagination": "113-148", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1030115617"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-1-4899-2406-3_5"
        ]
      }
    ], 
    "publisher": {
      "name": "Springer Nature", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-1-4899-2406-3_5", 
      "https://app.dimensions.ai/details/publication/pub.1030115617"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2022-10-01T06:57", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/chapter/chapter_366.jsonl", 
    "type": "Chapter", 
    "url": "https://doi.org/10.1007/978-1-4899-2406-3_5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4899-2406-3_5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4899-2406-3_5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4899-2406-3_5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4899-2406-3_5'


 

This table displays all metadata directly associated to this object as RDF triples.

123 TRIPLES      22 PREDICATES      65 URIs      58 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-1-4899-2406-3_5 schema:about anzsrc-for:11
2 anzsrc-for:1107
3 schema:author Nbb95a42a7d29461fb86af9f911780da3
4 schema:datePublished 1993
5 schema:datePublishedReg 1993-01-01
6 schema:description In mammals, ultraviolet-B radiation impacts on the skin and on the eyes (Zigman, Chapter 6 this volume). Because of effective absorption by skin components, very little of the incident UV-B penetrates beyond the epidermis. In spite of this, UV-B radiation is intimately linked with the mammalian immune system. In this chapter, we will describe a specific immunosuppression initiated by UV-B and discuss the mechanism of its generation. UV-B-induced immunosuppression may be a fundamental biological regulatory mechanism, designed to protect against autoimmune attack on sunlight-altered skin, the adverse effect of which is to permit the outgrowth of UV-induced skin cancers. In addition to this specific immunosuppression, irradiation with UV-B also releases a number of cytokines and induces the expression on keratinocytes of cell-surface immunologic receptors, which may be of significance in UV-related dermatologie disorders.
7 schema:editor Ne3fc6168bffa400b975f55990b28e83f
8 schema:genre chapter
9 schema:isAccessibleForFree false
10 schema:isPartOf Nf3fa76e94c214b8caf0638fd64fad9a0
11 schema:keywords UV
12 UV-Induced Immunosuppression
13 UV-induced skin cancer
14 absorption
15 addition
16 adverse effects
17 attacks
18 autoimmune attack
19 biological regulatory mechanisms
20 cancer
21 chapter
22 components
23 cytokines
24 disorders
25 effect
26 effective absorption
27 epidermis
28 expression
29 eyes
30 generation
31 immune system
32 immunosuppression
33 impact
34 incidents
35 irradiation
36 keratinocytes
37 mammalian immune system
38 mammals
39 mechanism
40 number
41 number of cytokines
42 outgrowth
43 radiation impact
44 receptors
45 regulatory mechanisms
46 significance
47 skin
48 skin cancer
49 skin components
50 specific immunosuppression
51 spite
52 system
53 schema:name UV-Induced Immunosuppression
54 schema:pagination 113-148
55 schema:productId N0ca654ea279843a6abb12239e7c78471
56 N9e59b2ae4f96458ca06c679463226bbb
57 schema:publisher N8c79c02a6b97450ca629c53f7f6380bf
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030115617
59 https://doi.org/10.1007/978-1-4899-2406-3_5
60 schema:sdDatePublished 2022-10-01T06:57
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher Nc345fe18a0044c1d813a68c22578564f
63 schema:url https://doi.org/10.1007/978-1-4899-2406-3_5
64 sgo:license sg:explorer/license/
65 sgo:sdDataset chapters
66 rdf:type schema:Chapter
67 N0ca654ea279843a6abb12239e7c78471 schema:name doi
68 schema:value 10.1007/978-1-4899-2406-3_5
69 rdf:type schema:PropertyValue
70 N25e610ab80e747f8bcdaf533885e6995 schema:familyName Moan
71 schema:givenName Johan
72 rdf:type schema:Person
73 N417b263c42ac47dc9b6c4a3be68ba07b rdf:first N25e610ab80e747f8bcdaf533885e6995
74 rdf:rest N93fb7ffc8b7943c3aedc4f580f5d0b18
75 N6c0f0df8589c41b784546bbfd3a6068b schema:familyName Young
76 schema:givenName Antony R.
77 rdf:type schema:Person
78 N7c72e6e685854b57986d9a462d5c3f04 rdf:first Nb9a0841fee0d42eb8c399052c8b24f84
79 rdf:rest rdf:nil
80 N8c79c02a6b97450ca629c53f7f6380bf schema:name Springer Nature
81 rdf:type schema:Organisation
82 N93fb7ffc8b7943c3aedc4f580f5d0b18 rdf:first Nc301d3bc0c604889917d2900f74eb063
83 rdf:rest N7c72e6e685854b57986d9a462d5c3f04
84 N9e59b2ae4f96458ca06c679463226bbb schema:name dimensions_id
85 schema:value pub.1030115617
86 rdf:type schema:PropertyValue
87 Nb9a0841fee0d42eb8c399052c8b24f84 schema:familyName Nultsch
88 schema:givenName Wilhelm
89 rdf:type schema:Person
90 Nbb95a42a7d29461fb86af9f911780da3 rdf:first sg:person.01004530501.09
91 rdf:rest Nc19deff5645545f38bb6c2788c5fc9f8
92 Nc19deff5645545f38bb6c2788c5fc9f8 rdf:first sg:person.074635015.51
93 rdf:rest rdf:nil
94 Nc301d3bc0c604889917d2900f74eb063 schema:familyName Björn
95 schema:givenName Lars Olof
96 rdf:type schema:Person
97 Nc345fe18a0044c1d813a68c22578564f schema:name Springer Nature - SN SciGraph project
98 rdf:type schema:Organization
99 Ne3fc6168bffa400b975f55990b28e83f rdf:first N6c0f0df8589c41b784546bbfd3a6068b
100 rdf:rest N417b263c42ac47dc9b6c4a3be68ba07b
101 Nf3fa76e94c214b8caf0638fd64fad9a0 schema:isbn 978-1-4899-2406-3
102 978-1-4899-2408-7
103 schema:name Environmental UV Photobiology
104 rdf:type schema:Book
105 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
106 schema:name Medical and Health Sciences
107 rdf:type schema:DefinedTerm
108 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
109 schema:name Immunology
110 rdf:type schema:DefinedTerm
111 sg:person.01004530501.09 schema:affiliation grid-institutes:grid.411841.9
112 schema:familyName Noonan
113 schema:givenName Frances P.
114 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004530501.09
115 rdf:type schema:Person
116 sg:person.074635015.51 schema:affiliation grid-institutes:grid.411841.9
117 schema:familyName De Fabo
118 schema:givenName Edward C.
119 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.074635015.51
120 rdf:type schema:Person
121 grid-institutes:grid.411841.9 schema:alternateName Laboratory of Photoimmunology and Photobiology, Department of Dermatology, The George Washington University Medical Center, 20037, Washington, DC, USA
122 schema:name Laboratory of Photoimmunology and Photobiology, Department of Dermatology, The George Washington University Medical Center, 20037, Washington, DC, USA
123 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...