Ontology type: schema:Chapter
1996
AUTHORSRichard A. Frazier , Martyn C. Davies , Gert Matthijs , Clive J. Roberts , Etienne Schacht , Simon Tasker , Saul J. B. Tendler
ABSTRACTDextran may be immobilized to a metal surface via thiol functionality introduced by chemical modification of hydroxyl groups on the polymer backbone. This paper details the characterization of thiolated dextrans, of molecular weights ranging 5 kDa to 500 kDa, chemisorbed to silver and their use as inhibitors of protein adsorption. Surface plasmon resonance (SPR) has been employed to monitor bovine serum albumin (BSA) adsorption from a flowing buffered solution. In addition, in situ SPR assays of any adsorbed BSA were carried out with anti-BSA antibody. The results obtained by SPR have been complemented and validated by ellipsometry, atomic force microscopy (AFM) and X-ray photoelectron spectroscopy (XPS) analysis. Whilst a significant reduction of BSA adsorption to dextran compared to the uncoated silver surface is observed, the degree of conversion of hydroxyls to thiol groups and molecular weight is seen to affect the nature and protein resistant performance of the dextran layer. By increasing the proportion of thiol substituents, a greater coverage is observed, conferring improved protein resistance. Higher molecular weight dextrans are shown to pack less efficiently to produce layers with less effective protein resistance. More... »
PAGES117-127
Surface Modification of Polymeric Biomaterials
ISBN
978-1-4899-1955-7
978-1-4899-1953-3
http://scigraph.springernature.com/pub.10.1007/978-1-4899-1953-3_14
DOIhttp://dx.doi.org/10.1007/978-1-4899-1953-3_14
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1012328035
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0306",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Physical Chemistry (incl. Structural)",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Chemical Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University of Nottingham",
"id": "https://www.grid.ac/institutes/grid.4563.4",
"name": [
"Laboratory of Biophysics and Surface Analysis, Department of Pharmaceutical Sciences, The University of Nottingham, University Park Nottingham, NG7 2RD, UK"
],
"type": "Organization"
},
"familyName": "Frazier",
"givenName": "Richard A.",
"id": "sg:person.0771554370.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771554370.76"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Nottingham",
"id": "https://www.grid.ac/institutes/grid.4563.4",
"name": [
"Laboratory of Biophysics and Surface Analysis, Department of Pharmaceutical Sciences, The University of Nottingham, University Park Nottingham, NG7 2RD, UK"
],
"type": "Organization"
},
"familyName": "Davies",
"givenName": "Martyn C.",
"id": "sg:person.01367077636.60",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367077636.60"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ghent University",
"id": "https://www.grid.ac/institutes/grid.5342.0",
"name": [
"Biomaterial and Polymer Research Group, Department of Organic Chemistry, University of Ghent, Krijgslaan 281, B-9000\u00a0Ghent, Belgium"
],
"type": "Organization"
},
"familyName": "Matthijs",
"givenName": "Gert",
"id": "sg:person.014645023326.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014645023326.50"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Nottingham",
"id": "https://www.grid.ac/institutes/grid.4563.4",
"name": [
"Laboratory of Biophysics and Surface Analysis, Department of Pharmaceutical Sciences, The University of Nottingham, University Park Nottingham, NG7 2RD, UK"
],
"type": "Organization"
},
"familyName": "Roberts",
"givenName": "Clive J.",
"id": "sg:person.01035336303.18",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035336303.18"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ghent University",
"id": "https://www.grid.ac/institutes/grid.5342.0",
"name": [
"Biomaterial and Polymer Research Group, Department of Organic Chemistry, University of Ghent, Krijgslaan 281, B-9000\u00a0Ghent, Belgium"
],
"type": "Organization"
},
"familyName": "Schacht",
"givenName": "Etienne",
"id": "sg:person.01262432466.39",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262432466.39"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Nottingham",
"id": "https://www.grid.ac/institutes/grid.4563.4",
"name": [
"Laboratory of Biophysics and Surface Analysis, Department of Pharmaceutical Sciences, The University of Nottingham, University Park Nottingham, NG7 2RD, UK"
],
"type": "Organization"
},
"familyName": "Tasker",
"givenName": "Simon",
"id": "sg:person.012307100616.47",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012307100616.47"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Nottingham",
"id": "https://www.grid.ac/institutes/grid.4563.4",
"name": [
"Laboratory of Biophysics and Surface Analysis, Department of Pharmaceutical Sciences, The University of Nottingham, University Park Nottingham, NG7 2RD, UK"
],
"type": "Organization"
},
"familyName": "Tendler",
"givenName": "Saul J. B.",
"id": "sg:person.015425322167.24",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015425322167.24"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/s0003-2670(00)81337-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000000478"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/macp.1985.021861205",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001433682"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0264-410x(94)90237-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013331773"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0264-410x(94)90237-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013331773"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0022-1759(91)90331-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014976156"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0022-1759(91)90331-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014976156"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/macp.1994.021950118",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016323522"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0021-9673(92)80137-j",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023275328"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1163/156856294x00509",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026008496"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1149/1.2086000",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027270969"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0927-7757(93)80111-q",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028042164"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0927-7757(93)80112-r",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032641661"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0030-4018(91)90353-f",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040841311"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0030-4018(91)90353-f",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040841311"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0022-2860(90)80291-q",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044576899"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0032-3861(74)90134-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045711403"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0032-3861(74)90134-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045711403"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/bc00023a016",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1055152921"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/ja00019a011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1055699533"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/ja00040a058",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1055701422"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/ja00183a049",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1055712217"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/ja00246a011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1055717318"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/la00018a030",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1056137463"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/la00018a034",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1056137467"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/la00023a035",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1056137868"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/la00025a032",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1056138018"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/la00032a005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1056138391"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/la00033a018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1056138471"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/la00035a072",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1056138619"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/la00055a022",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1056139677"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/la00058a074",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1056139870"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/ma00058a005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1056175167"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/ma00073a043",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1056176030"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/ma00116a033",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1056178421"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/ma00183a003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1056182083"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1103/physrevb.39.1006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1060548444"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1103/physrevb.39.1006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1060548444"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3891/acta.chem.scand.22-1907",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071492664"
],
"type": "CreativeWork"
}
],
"datePublished": "1996",
"datePublishedReg": "1996-01-01",
"description": "Dextran may be immobilized to a metal surface via thiol functionality introduced by chemical modification of hydroxyl groups on the polymer backbone. This paper details the characterization of thiolated dextrans, of molecular weights ranging 5 kDa to 500 kDa, chemisorbed to silver and their use as inhibitors of protein adsorption. Surface plasmon resonance (SPR) has been employed to monitor bovine serum albumin (BSA) adsorption from a flowing buffered solution. In addition, in situ SPR assays of any adsorbed BSA were carried out with anti-BSA antibody. The results obtained by SPR have been complemented and validated by ellipsometry, atomic force microscopy (AFM) and X-ray photoelectron spectroscopy (XPS) analysis. Whilst a significant reduction of BSA adsorption to dextran compared to the uncoated silver surface is observed, the degree of conversion of hydroxyls to thiol groups and molecular weight is seen to affect the nature and protein resistant performance of the dextran layer. By increasing the proportion of thiol substituents, a greater coverage is observed, conferring improved protein resistance. Higher molecular weight dextrans are shown to pack less efficiently to produce layers with less effective protein resistance.",
"editor": [
{
"familyName": "Ratner",
"givenName": "Buddy D.",
"type": "Person"
},
{
"familyName": "Castner",
"givenName": "David G.",
"type": "Person"
}
],
"genre": "chapter",
"id": "sg:pub.10.1007/978-1-4899-1953-3_14",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": {
"isbn": [
"978-1-4899-1955-7",
"978-1-4899-1953-3"
],
"name": "Surface Modification of Polymeric Biomaterials",
"type": "Book"
},
"name": "The Self-Assembly and Inhibition of Protein Adsorption by Thiolated Dextran Monolayers at Hydrophobic Metal Surfaces",
"pagination": "117-127",
"productId": [
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/978-1-4899-1953-3_14"
]
},
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"3abbfed0d9367ff53833ecf89aba76b7af99b18c724a971477d6f7f1d175d1e4"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1012328035"
]
}
],
"publisher": {
"location": "Boston, MA",
"name": "Springer US",
"type": "Organisation"
},
"sameAs": [
"https://doi.org/10.1007/978-1-4899-1953-3_14",
"https://app.dimensions.ai/details/publication/pub.1012328035"
],
"sdDataset": "chapters",
"sdDatePublished": "2019-04-15T11:32",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000250.jsonl",
"type": "Chapter",
"url": "http://link.springer.com/10.1007/978-1-4899-1953-3_14"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4899-1953-3_14'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4899-1953-3_14'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4899-1953-3_14'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4899-1953-3_14'
This table displays all metadata directly associated to this object as RDF triples.
214 TRIPLES
23 PREDICATES
60 URIs
20 LITERALS
8 BLANK NODES