Novel Superantigens from Streptococcal Toxic Shock Syndrome Streptococcus pyogenes Isolates View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1997

AUTHORS

Duane Newton , Anna Norrby-Teglund , Allison McGeer , Donald E. Low , Patrick M. Schlievert , Malak Kotb

ABSTRACT

The incidence of severe invasive group A streptococcal infections (GAS) and streptococcal toxic shock syndrome (STSS) continues to rise (1), but the reason for this impressive change in epidemiology and clinical manifestation of GAS infections remains a mystery. Streptococcal superantigens (SAgs) have been implicated in the pathogenesis of STSS, but no single SAg can be directly associated with disease (reviewed in 2). A recent outbreak of severe GAS infections in Canada since November 1994 has led to the identification of 95 patients with invasive GAS infections or STSS. These invasive cases could be classified into severe and nonsevere invasive disease based on the clinical symptoms. The severe cases included patients with STSS and necrotizing fasciitis whereas the nonsevere cases were those with no sign of hypotension, organ failure, deep soft tissue involvement or shock. In this study we examined the distribution of genes encoding known streptococcal pyrogenic exotoxins (Spes), which belong to the family of microbial superantigens, among isolates from severe and nonsevere disease. In addition, we investigated the pattern of SAg production by GAS strains isolated from these patients. We report that invasive strains of S. pyogenes produce a number of known Spes as well as novel SAgs that remain to be fully characterized. More... »

PAGES

525-9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4899-1825-3_123

DOI

http://dx.doi.org/10.1007/978-1-4899-1825-3_123

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015268238

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9331707


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