The New Generation of Recombinant Pertussis Vaccines View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1994

AUTHORS

Sheena Loosmore , Gavin Zealey , Michel Klein

ABSTRACT

Whooping cough or pertussis is a severe, highly contagious upper respiratory tract infections, mainly affecting young children. The World Health Organization estimates that there are 60 million cases of pertussis per year and 0.5-1 million associated deaths (Muller et al., 1986). In unvaccinated populations, an incidence rate as high as 80% has been observed in children under 5 years old (Fine and Clarkson, 1984). The disease has two distinct phases, the early phase or catarrhal stage, lasts up to two weeks with symptoms of low-grade fever and mild cough. The second phase is the paroxysmal stage which can last for 4–6 weeks and is accompanied by the characteristic whoop. Infants, in particular, an suffer apnoea and hypoxaemia during these prolonged coughing bouts and there is a 5% incidence of serious neurological complications. Although pertussis is considered to be a childhood disease, there is increasing evidence of clinical and asymptomatic disease in adolescents and adults (Mortimer, 1990; Addiss et al., 1991; Halperin and Marrie, 1991). Erythromycin treatment is effective in clearing bacteria but has little effect on symptoms. Passive immunotherapy, on the other hand has been shown to reduce the frequency and severity of whoops (Granstrom et al., 1991). More... »

PAGES

319-340

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4899-1450-7_17

DOI

http://dx.doi.org/10.1007/978-1-4899-1450-7_17

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045964506


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