A Phase II Trial of Autologous Bone Marrow Transplantation (ABMT) in Acute Leukemia with Edelfosine Purged Bone Marrow View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1996

AUTHORS

William R. Vogler , Wolfgang E. Berdel , Robert B. Geller , Joel A. Brochstein , Roy A. Beveridge , William S. Dalton , Kenneth B. Miller , Hillard M. Lazarus

ABSTRACT

Alkyl-lysophospholipid compounds which are selectively cytotoxic to neoplastic cells and relatively sparing of normal marrow progenitor cells are appealing as purging agents to rid remission marrows of residual leukemic cells. A multi-institutional phase II study was conducted in 57 patients with acute leukemia (50 AML and 7 ALL) in which remission marrows were purged in vitro and reinfused after ablative chemotherapy. The median time for granulocyte recovery to 500/microliter was 33 days and for platelet recovery to 25000/microliter was 46 days. The overall DFS and survival was 37% and 46% respectively. Transplantation in first remission gave a better survival than transplant in a subsequent remission. More... »

PAGES

389-96

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4899-0179-8_62

DOI

http://dx.doi.org/10.1007/978-1-4899-0179-8_62

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011558364

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9131178


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