Heterocyclic Alkylphospholipids with an Improved Therapeutic Range View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1996

AUTHORS

P. Hilgard , J. Stekar , T. Klenner , G. Nössner , B. Kutscher , J. Engel

ABSTRACT

Hexadecylphosphocholine (INN: Miltefosine) is the prototype of a new class of antitumor phospholipids. Its specificially formulated solution (Miltex®) is an approved drug in Germany and has become a valuable tool in the treatment of cutaneous breast cancer and other malignant lesions (1). The systemic treatment with an oral miltefosine formulation was, however, relatively toxic to the GI-tract. Therefore, the drug could not be adequately dosed and in initial clinical studies the overall response rates remained low (2). More... »

PAGES

157-64

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4899-0179-8_26

DOI

http://dx.doi.org/10.1007/978-1-4899-0179-8_26

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004744781

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9131142


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heterocyclic Compounds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phospholipids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylcholine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Evonik (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420017.0", 
          "name": [
            "Experimental Cancer Reseach Department, ASTA Medica AG, Weism\u00fcllerstr. 45, D-60314\u00a0Frankfurt am Main, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hilgard", 
        "givenName": "P.", 
        "id": "sg:person.01023655171.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023655171.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Evonik (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420017.0", 
          "name": [
            "Experimental Cancer Reseach Department, ASTA Medica AG, Weism\u00fcllerstr. 45, D-60314\u00a0Frankfurt am Main, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stekar", 
        "givenName": "J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Evonik (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420017.0", 
          "name": [
            "Experimental Cancer Reseach Department, ASTA Medica AG, Weism\u00fcllerstr. 45, D-60314\u00a0Frankfurt am Main, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Klenner", 
        "givenName": "T.", 
        "id": "sg:person.0623203132.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623203132.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Evonik (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420017.0", 
          "name": [
            "Experimental Cancer Reseach Department, ASTA Medica AG, Weism\u00fcllerstr. 45, D-60314\u00a0Frankfurt am Main, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "N\u00f6ssner", 
        "givenName": "G.", 
        "id": "sg:person.0577656214.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577656214.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Evonik (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420017.0", 
          "name": [
            "Experimental Cancer Reseach Department, ASTA Medica AG, Weism\u00fcllerstr. 45, D-60314\u00a0Frankfurt am Main, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kutscher", 
        "givenName": "B.", 
        "id": "sg:person.01371072254.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371072254.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Evonik (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420017.0", 
          "name": [
            "Experimental Cancer Reseach Department, ASTA Medica AG, Weism\u00fcllerstr. 45, D-60314\u00a0Frankfurt am Main, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Engel", 
        "givenName": "J.", 
        "id": "sg:person.011670303512.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011670303512.58"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00685887", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005452257", 
          "https://doi.org/10.1007/bf00685887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00685887", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005452257", 
          "https://doi.org/10.1007/bf00685887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-8049(05)80369-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025460998"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1996", 
    "datePublishedReg": "1996-01-01", 
    "description": "Hexadecylphosphocholine (INN: Miltefosine) is the prototype of a new class of antitumor phospholipids. Its specificially formulated solution (Miltex\u00ae) is an approved drug in Germany and has become a valuable tool in the treatment of cutaneous breast cancer and other malignant lesions (1). The systemic treatment with an oral miltefosine formulation was, however, relatively toxic to the GI-tract. Therefore, the drug could not be adequately dosed and in initial clinical studies the overall response rates remained low (2).", 
    "editor": [
      {
        "familyName": "Nigam", 
        "givenName": "Santosh", 
        "type": "Person"
      }, 
      {
        "familyName": "Kunkel", 
        "givenName": "Gert", 
        "type": "Person"
      }, 
      {
        "familyName": "Prescott", 
        "givenName": "Stephen M.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-1-4899-0179-8_26", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-1-4899-0181-1", 
        "978-1-4899-0179-8"
      ], 
      "name": "Platelet-Activating Factor and Related Lipid Mediators 2", 
      "type": "Book"
    }, 
    "name": "Heterocyclic Alkylphospholipids with an Improved Therapeutic Range", 
    "pagination": "157-64", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-1-4899-0179-8_26"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "169bc7270619eadcbc030d2b1d18a02256eb3ab9eba5a5a331d1e53da0c95042"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1004744781"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9131142"
        ]
      }
    ], 
    "publisher": {
      "location": "Boston, MA", 
      "name": "Springer US", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-1-4899-0179-8_26", 
      "https://app.dimensions.ai/details/publication/pub.1004744781"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-15T20:58", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000237.jsonl", 
    "type": "Chapter", 
    "url": "http://link.springer.com/10.1007/978-1-4899-0179-8_26"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4899-0179-8_26'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4899-0179-8_26'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4899-0179-8_26'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4899-0179-8_26'


 

This table displays all metadata directly associated to this object as RDF triples.

148 TRIPLES      23 PREDICATES      37 URIs      28 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-1-4899-0179-8_26 schema:about N358b9c9abe354ea39dc2eb14c8013f7b
2 N4df07b7fcde349639cc9725903c1b84d
3 N60151a637edd4dd78533e12b4100a8cc
4 N773b43316fde4b3a9cfadb9bf9859937
5 Naf2cacc3d74e42388c51473d329123de
6 Nf902538cc56143bb9105d18f9ed9442d
7 Nfee698f4385349bcbc06fe216cc31c69
8 anzsrc-for:11
9 anzsrc-for:1112
10 schema:author N153db0915ffc4cc3bad1f2773c85b650
11 schema:citation sg:pub.10.1007/bf00685887
12 https://doi.org/10.1016/s0959-8049(05)80369-7
13 schema:datePublished 1996
14 schema:datePublishedReg 1996-01-01
15 schema:description Hexadecylphosphocholine (INN: Miltefosine) is the prototype of a new class of antitumor phospholipids. Its specificially formulated solution (Miltex®) is an approved drug in Germany and has become a valuable tool in the treatment of cutaneous breast cancer and other malignant lesions (1). The systemic treatment with an oral miltefosine formulation was, however, relatively toxic to the GI-tract. Therefore, the drug could not be adequately dosed and in initial clinical studies the overall response rates remained low (2).
16 schema:editor Neeec567cff8a4ca886aae7706d27b34c
17 schema:genre chapter
18 schema:inLanguage en
19 schema:isAccessibleForFree false
20 schema:isPartOf Ndff4340f7b5046c4af6cefc11a33f645
21 schema:name Heterocyclic Alkylphospholipids with an Improved Therapeutic Range
22 schema:pagination 157-64
23 schema:productId N3f47e7421b6846edad0e9b8fbc508506
24 N7cf40fdb60024203afe29ac5e59b23ae
25 Nd69d4f7a7f2b44028c1c913a438fdb84
26 Nea40634c1c7848869d3153792413286e
27 schema:publisher N7655a5c2f7554ba98747e8db8a23e652
28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004744781
29 https://doi.org/10.1007/978-1-4899-0179-8_26
30 schema:sdDatePublished 2019-04-15T20:58
31 schema:sdLicense https://scigraph.springernature.com/explorer/license/
32 schema:sdPublisher N4eaa16fa851d4864a25b4e103b60b54e
33 schema:url http://link.springer.com/10.1007/978-1-4899-0179-8_26
34 sgo:license sg:explorer/license/
35 sgo:sdDataset chapters
36 rdf:type schema:Chapter
37 N153db0915ffc4cc3bad1f2773c85b650 rdf:first sg:person.01023655171.21
38 rdf:rest Na0369fe44872482cac6eb738d1dfc098
39 N2c46d4ec80ce45bab0539fec9f2bc077 rdf:first sg:person.0577656214.75
40 rdf:rest N9decc18664a44d6facbd753a27ce111a
41 N358b9c9abe354ea39dc2eb14c8013f7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
42 schema:name Animals
43 rdf:type schema:DefinedTerm
44 N3f47e7421b6846edad0e9b8fbc508506 schema:name readcube_id
45 schema:value 169bc7270619eadcbc030d2b1d18a02256eb3ab9eba5a5a331d1e53da0c95042
46 rdf:type schema:PropertyValue
47 N4a76ba98c15c4e408ad45d2bb23833b4 schema:familyName Kunkel
48 schema:givenName Gert
49 rdf:type schema:Person
50 N4df07b7fcde349639cc9725903c1b84d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
51 schema:name Antineoplastic Agents
52 rdf:type schema:DefinedTerm
53 N4eaa16fa851d4864a25b4e103b60b54e schema:name Springer Nature - SN SciGraph project
54 rdf:type schema:Organization
55 N60151a637edd4dd78533e12b4100a8cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
56 schema:name Humans
57 rdf:type schema:DefinedTerm
58 N7655a5c2f7554ba98747e8db8a23e652 schema:location Boston, MA
59 schema:name Springer US
60 rdf:type schema:Organisation
61 N773b43316fde4b3a9cfadb9bf9859937 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
62 schema:name Phosphorylcholine
63 rdf:type schema:DefinedTerm
64 N7cf40fdb60024203afe29ac5e59b23ae schema:name doi
65 schema:value 10.1007/978-1-4899-0179-8_26
66 rdf:type schema:PropertyValue
67 N7fb08b271bc248848c6e1a4e6cb0a58a schema:familyName Prescott
68 schema:givenName Stephen M.
69 rdf:type schema:Person
70 N9decc18664a44d6facbd753a27ce111a rdf:first sg:person.01371072254.40
71 rdf:rest Nb0ea571872e64d969f3690b32744d4e3
72 Na0369fe44872482cac6eb738d1dfc098 rdf:first Nc4b68296997f4703a877b7e290c8197a
73 rdf:rest Ne52f329c47c84077a9851411d2aa859a
74 Naf2cacc3d74e42388c51473d329123de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Tumor Cells, Cultured
76 rdf:type schema:DefinedTerm
77 Nb0ea571872e64d969f3690b32744d4e3 rdf:first sg:person.011670303512.58
78 rdf:rest rdf:nil
79 Nbe54bc1d48ed436c8859be646647d9fa rdf:first N4a76ba98c15c4e408ad45d2bb23833b4
80 rdf:rest Ne2fc45286fb64b7f940bca77c4ef3eca
81 Nc4b68296997f4703a877b7e290c8197a schema:affiliation https://www.grid.ac/institutes/grid.420017.0
82 schema:familyName Stekar
83 schema:givenName J.
84 rdf:type schema:Person
85 Nd69d4f7a7f2b44028c1c913a438fdb84 schema:name dimensions_id
86 schema:value pub.1004744781
87 rdf:type schema:PropertyValue
88 Ndff4340f7b5046c4af6cefc11a33f645 schema:isbn 978-1-4899-0179-8
89 978-1-4899-0181-1
90 schema:name Platelet-Activating Factor and Related Lipid Mediators 2
91 rdf:type schema:Book
92 Ne2fc45286fb64b7f940bca77c4ef3eca rdf:first N7fb08b271bc248848c6e1a4e6cb0a58a
93 rdf:rest rdf:nil
94 Ne52f329c47c84077a9851411d2aa859a rdf:first sg:person.0623203132.25
95 rdf:rest N2c46d4ec80ce45bab0539fec9f2bc077
96 Nea40634c1c7848869d3153792413286e schema:name pubmed_id
97 schema:value 9131142
98 rdf:type schema:PropertyValue
99 Neadc4397d5aa4675bd74d25cbc890e24 schema:familyName Nigam
100 schema:givenName Santosh
101 rdf:type schema:Person
102 Neeec567cff8a4ca886aae7706d27b34c rdf:first Neadc4397d5aa4675bd74d25cbc890e24
103 rdf:rest Nbe54bc1d48ed436c8859be646647d9fa
104 Nf902538cc56143bb9105d18f9ed9442d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Heterocyclic Compounds
106 rdf:type schema:DefinedTerm
107 Nfee698f4385349bcbc06fe216cc31c69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Phospholipids
109 rdf:type schema:DefinedTerm
110 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
111 schema:name Medical and Health Sciences
112 rdf:type schema:DefinedTerm
113 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
114 schema:name Oncology and Carcinogenesis
115 rdf:type schema:DefinedTerm
116 sg:person.01023655171.21 schema:affiliation https://www.grid.ac/institutes/grid.420017.0
117 schema:familyName Hilgard
118 schema:givenName P.
119 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023655171.21
120 rdf:type schema:Person
121 sg:person.011670303512.58 schema:affiliation https://www.grid.ac/institutes/grid.420017.0
122 schema:familyName Engel
123 schema:givenName J.
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011670303512.58
125 rdf:type schema:Person
126 sg:person.01371072254.40 schema:affiliation https://www.grid.ac/institutes/grid.420017.0
127 schema:familyName Kutscher
128 schema:givenName B.
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371072254.40
130 rdf:type schema:Person
131 sg:person.0577656214.75 schema:affiliation https://www.grid.ac/institutes/grid.420017.0
132 schema:familyName Nössner
133 schema:givenName G.
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577656214.75
135 rdf:type schema:Person
136 sg:person.0623203132.25 schema:affiliation https://www.grid.ac/institutes/grid.420017.0
137 schema:familyName Klenner
138 schema:givenName T.
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623203132.25
140 rdf:type schema:Person
141 sg:pub.10.1007/bf00685887 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005452257
142 https://doi.org/10.1007/bf00685887
143 rdf:type schema:CreativeWork
144 https://doi.org/10.1016/s0959-8049(05)80369-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025460998
145 rdf:type schema:CreativeWork
146 https://www.grid.ac/institutes/grid.420017.0 schema:alternateName Evonik (Germany)
147 schema:name Experimental Cancer Reseach Department, ASTA Medica AG, Weismüllerstr. 45, D-60314 Frankfurt am Main, Germany
148 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...