Protection Against Tuberculosis by Plasmid DNA View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1997

AUTHORS

R. E. Tascon , M. J. Colston , E. Stavropoulos , S. Ragno , D. Gregory , D. B. Lowrie

ABSTRACT

The availability of cloned mycobacterial genes and suitable vectors for expression in mammalian cells has now opened a new avenue in which individual mycobacterial protein antigens can be tested for their ability to confer protective immunity. Expression of protection against mycobacteria is largely a function of antigen specific CD4 and cytotoxic CD8 T cells. We have found that intramuscular injection of plasmid DNA expressing several mycobacterial immunodominant genes can induce both T cell populations and confer protection equivalent to BCG, suggesting that this approach may lead to a new vaccine. More... »

PAGES

181-185

References to SciGraph publications

Book

TITLE

Vaccine Design

ISBN

978-1-4899-0064-7
978-1-4899-0062-3

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4899-0062-3_18

DOI

http://dx.doi.org/10.1007/978-1-4899-0062-3_18

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043364320


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