“Brain-Tissue-Specific” Versus “Serum-Specific” Posttranslational Modification of Human Cerebrospinal Fluid Polypeptides with N-Linked Carbohydrates View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1996

AUTHORS

Andrea Hoffmann , Eckart Grabenhorst , Manfred Nimtz , Harald S. Conradt

ABSTRACT

Comparison of the patterns of N-linked oligosaccharides attached to several proteins isolated from human cerebrospinal fluid and serum reveals striking differences (“brain-type” versus “serum-type” glycosylation) which are attributed to the different physiological surroundings of both body fluids. No modification of oligosaccharides was found to occur during passage of proteins across the blood-brain barrier. Glycosylation analysis of CSF-proteins can thus be used to gain information on the site of biosynthesis (i.e. systemic or intrathecal) of specific proteins in question. More... »

PAGES

103-107

Book

TITLE

Biology and Physiology of the Blood-Brain Barrier

ISBN

978-1-4757-9491-5
978-1-4757-9489-2

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4757-9489-2_18

DOI

http://dx.doi.org/10.1007/978-1-4757-9489-2_18

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017228375


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