Biochemical Studies on the Muscarinic Acetylcholine Receptor View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1988

AUTHORS

T. Haga , G. Berstein , T. Nishiyama , H. Uchiyama , K. Ohara , K. Haga

ABSTRACT

The muscarinic acetylcholine receptor was functionally defined, based on the actions of specific drugs on specific cells or tissues (for a review, see ref. 1). The development of specific radio-labeled ligands (2,3) enabled us to estimate and characterize the ligand-binding sites independently of their functions. Quantitative analysis of the binding of specific ligands with membrane preparations allowed to define at least three different subtypes of muscarinic receptors (4,5), and the regional distribution of these subtypes was also determined (6,7). Although different kinds of actions are known to be elicited by muscarinic agonists depending on species of cells or tissues, the relation between the subtypes and the actions elicited by their activation is not straightforward so far (for example, see ref. 8). More... »

PAGES

239-254

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4757-5971-6_19

DOI

http://dx.doi.org/10.1007/978-1-4757-5971-6_19

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000335413

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3149141


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