Roles of adenosine and nitric oxide in skeletal muscle in acute and chronic hypoxia View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2001

AUTHORS

Janice M. Marshall

ABSTRACT

In experiments on anaesthetised rats, the roles played by adenosine and nitric oxide (NO) were determined in resting skeletal muscle in acute systemic hypoxia and during acclimation to chronic systemic hypoxia. It is concluded that adenosine acting on A1 receptors, at least in part in an NO-dependent manner, plays essential roles in causing the dilation of proximal and terminal arterioles that helps to maintain muscle O2 consumption when O2 delivery is reduced by acute systemic hypoxia. It is proposed that adenosine and NO are similarly responsible for causing the tonic vasodilation that gradually wanes in the first 7 days of chronic hypoxia and that concomitantly, adenosine and hypoxia stimulate VEGF expression, so increasing venular permeability and triggering angiogenesis. By 7 days of chronic hypoxia, arteriolar remodelling is well established and within 18–21 days, substantial capillary angiogenesis alleviates tissue hypoxia. At this time, vasoconstrictor responses to the sympathetic transmitter norepinephrine are reduced, but dilator responses to adenosine released by acute hypoxia are enhanced, as may be explained by increased sensitivity to NO. Thus, preservation of tissue oxygenation is apparently associated with impaired ability to regulate arterial pressure and vulnerability to further hypoxia. More... »

PAGES

349-363

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4757-3401-0_23

DOI

http://dx.doi.org/10.1007/978-1-4757-3401-0_23

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004590476

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11950149


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1116", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Physiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acute Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenosine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chronic Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypoxia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle, Skeletal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nitric Oxide", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Physiology, The Medical School, Birmingham, UK", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Physiology, The Medical School, Birmingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marshall", 
        "givenName": "Janice M.", 
        "id": "sg:person.0753431202.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753431202.20"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2001", 
    "datePublishedReg": "2001-01-01", 
    "description": "In experiments on anaesthetised rats, the roles played by adenosine and nitric oxide (NO) were determined in resting skeletal muscle in acute systemic hypoxia and during acclimation to chronic systemic hypoxia. It is concluded that adenosine acting on A1 receptors, at least in part in an NO-dependent manner, plays essential roles in causing the dilation of proximal and terminal arterioles that helps to maintain muscle O2 consumption when O2 delivery is reduced by acute systemic hypoxia. It is proposed that adenosine and NO are similarly responsible for causing the tonic vasodilation that gradually wanes in the first 7 days of chronic hypoxia and that concomitantly, adenosine and hypoxia stimulate VEGF expression, so increasing venular permeability and triggering angiogenesis. By 7 days of chronic hypoxia, arteriolar remodelling is well established and within 18\u201321 days, substantial capillary angiogenesis alleviates tissue hypoxia. At this time, vasoconstrictor responses to the sympathetic transmitter norepinephrine are reduced, but dilator responses to adenosine released by acute hypoxia are enhanced, as may be explained by increased sensitivity to NO. Thus, preservation of tissue oxygenation is apparently associated with impaired ability to regulate arterial pressure and vulnerability to further hypoxia.", 
    "editor": [
      {
        "familyName": "Roach", 
        "givenName": "Robert C.", 
        "type": "Person"
      }, 
      {
        "familyName": "Wagner", 
        "givenName": "Peter D.", 
        "type": "Person"
      }, 
      {
        "familyName": "Hackett", 
        "givenName": "Peter H.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-1-4757-3401-0_23", 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-1-4419-3374-4", 
        "978-1-4757-3401-0"
      ], 
      "name": "Hypoxia", 
      "type": "Book"
    }, 
    "keywords": [
      "acute systemic hypoxia", 
      "systemic hypoxia", 
      "chronic hypoxia", 
      "nitric oxide", 
      "chronic systemic hypoxia", 
      "sympathetic transmitter norepinephrine", 
      "skeletal muscle", 
      "role of adenosine", 
      "NO-dependent manner", 
      "muscle O2 consumption", 
      "arteriolar remodelling", 
      "vasoconstrictor responses", 
      "dilator response", 
      "arterial pressure", 
      "acute hypoxia", 
      "tissue hypoxia", 
      "transmitter norepinephrine", 
      "A1 receptors", 
      "tonic vasodilation", 
      "tissue oxygenation", 
      "further hypoxia", 
      "capillary angiogenesis", 
      "O2 delivery", 
      "terminal arterioles", 
      "VEGF expression", 
      "venular permeability", 
      "hypoxia", 
      "impaired ability", 
      "adenosine", 
      "O2 consumption", 
      "muscle", 
      "angiogenesis", 
      "days", 
      "vasodilation", 
      "norepinephrine", 
      "arterioles", 
      "rats", 
      "receptors", 
      "response", 
      "essential role", 
      "oxygenation", 
      "dilation", 
      "role", 
      "remodelling", 
      "delivery", 
      "expression", 
      "sensitivity", 
      "preservation", 
      "pressure", 
      "manner", 
      "ability", 
      "vulnerability", 
      "permeability", 
      "consumption", 
      "time", 
      "part", 
      "oxide", 
      "experiments", 
      "acclimation"
    ], 
    "name": "Roles of adenosine and nitric oxide in skeletal muscle in acute and chronic hypoxia", 
    "pagination": "349-363", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1004590476"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-1-4757-3401-0_23"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11950149"
        ]
      }
    ], 
    "publisher": {
      "name": "Springer Nature", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-1-4757-3401-0_23", 
      "https://app.dimensions.ai/details/publication/pub.1004590476"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2022-08-04T17:18", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/chapter/chapter_305.jsonl", 
    "type": "Chapter", 
    "url": "https://doi.org/10.1007/978-1-4757-3401-0_23"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4757-3401-0_23'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4757-3401-0_23'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4757-3401-0_23'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4757-3401-0_23'


 

This table displays all metadata directly associated to this object as RDF triples.

164 TRIPLES      22 PREDICATES      93 URIs      86 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-1-4757-3401-0_23 schema:about N00d9061e6bb648eda08786ac418a52d3
2 N34cae15cc9d34e39b847e40a63aa9198
3 N48253d37bc4b48f4a62e71fa9d4c016e
4 N6644c372fc4049229347b1d9546ead23
5 N72d2df6fc1d643f9a2413f1193c10861
6 N8c7646b030614fa2ba98314575b879d1
7 Nd4d0f44471aa4dcd93cfc7f95ff1ac9a
8 Ne4ca7740eea64f88a5225b82c759bf52
9 anzsrc-for:11
10 anzsrc-for:1116
11 schema:author Nf6a31724929f4f098862383ddec8e7da
12 schema:datePublished 2001
13 schema:datePublishedReg 2001-01-01
14 schema:description In experiments on anaesthetised rats, the roles played by adenosine and nitric oxide (NO) were determined in resting skeletal muscle in acute systemic hypoxia and during acclimation to chronic systemic hypoxia. It is concluded that adenosine acting on A1 receptors, at least in part in an NO-dependent manner, plays essential roles in causing the dilation of proximal and terminal arterioles that helps to maintain muscle O2 consumption when O2 delivery is reduced by acute systemic hypoxia. It is proposed that adenosine and NO are similarly responsible for causing the tonic vasodilation that gradually wanes in the first 7 days of chronic hypoxia and that concomitantly, adenosine and hypoxia stimulate VEGF expression, so increasing venular permeability and triggering angiogenesis. By 7 days of chronic hypoxia, arteriolar remodelling is well established and within 18–21 days, substantial capillary angiogenesis alleviates tissue hypoxia. At this time, vasoconstrictor responses to the sympathetic transmitter norepinephrine are reduced, but dilator responses to adenosine released by acute hypoxia are enhanced, as may be explained by increased sensitivity to NO. Thus, preservation of tissue oxygenation is apparently associated with impaired ability to regulate arterial pressure and vulnerability to further hypoxia.
15 schema:editor Na4259f9c31e344889d16d42d0a8f833c
16 schema:genre chapter
17 schema:isAccessibleForFree false
18 schema:isPartOf N6865129fe1b0468bb5d2c0821a17a49a
19 schema:keywords A1 receptors
20 NO-dependent manner
21 O2 consumption
22 O2 delivery
23 VEGF expression
24 ability
25 acclimation
26 acute hypoxia
27 acute systemic hypoxia
28 adenosine
29 angiogenesis
30 arterial pressure
31 arteriolar remodelling
32 arterioles
33 capillary angiogenesis
34 chronic hypoxia
35 chronic systemic hypoxia
36 consumption
37 days
38 delivery
39 dilation
40 dilator response
41 essential role
42 experiments
43 expression
44 further hypoxia
45 hypoxia
46 impaired ability
47 manner
48 muscle
49 muscle O2 consumption
50 nitric oxide
51 norepinephrine
52 oxide
53 oxygenation
54 part
55 permeability
56 preservation
57 pressure
58 rats
59 receptors
60 remodelling
61 response
62 role
63 role of adenosine
64 sensitivity
65 skeletal muscle
66 sympathetic transmitter norepinephrine
67 systemic hypoxia
68 terminal arterioles
69 time
70 tissue hypoxia
71 tissue oxygenation
72 tonic vasodilation
73 transmitter norepinephrine
74 vasoconstrictor responses
75 vasodilation
76 venular permeability
77 vulnerability
78 schema:name Roles of adenosine and nitric oxide in skeletal muscle in acute and chronic hypoxia
79 schema:pagination 349-363
80 schema:productId N1674c7511eb1486183a906b79fc24ce1
81 N4210353da31444dd8e4cfef738d81ee9
82 Naeaf3ef7b12247b8a6c0db92e6e0f0d5
83 schema:publisher N05f007777a6b41d699468561105f4627
84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004590476
85 https://doi.org/10.1007/978-1-4757-3401-0_23
86 schema:sdDatePublished 2022-08-04T17:18
87 schema:sdLicense https://scigraph.springernature.com/explorer/license/
88 schema:sdPublisher N1bd3823ed8014baa8cc930aa522bac62
89 schema:url https://doi.org/10.1007/978-1-4757-3401-0_23
90 sgo:license sg:explorer/license/
91 sgo:sdDataset chapters
92 rdf:type schema:Chapter
93 N00d9061e6bb648eda08786ac418a52d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Chronic Disease
95 rdf:type schema:DefinedTerm
96 N05f007777a6b41d699468561105f4627 schema:name Springer Nature
97 rdf:type schema:Organisation
98 N1674c7511eb1486183a906b79fc24ce1 schema:name dimensions_id
99 schema:value pub.1004590476
100 rdf:type schema:PropertyValue
101 N1bd3823ed8014baa8cc930aa522bac62 schema:name Springer Nature - SN SciGraph project
102 rdf:type schema:Organization
103 N34cae15cc9d34e39b847e40a63aa9198 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Muscle, Skeletal
105 rdf:type schema:DefinedTerm
106 N3f431365e8b8486f9ff61cef6f8d87d5 schema:familyName Wagner
107 schema:givenName Peter D.
108 rdf:type schema:Person
109 N4210353da31444dd8e4cfef738d81ee9 schema:name pubmed_id
110 schema:value 11950149
111 rdf:type schema:PropertyValue
112 N48253d37bc4b48f4a62e71fa9d4c016e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Animals
114 rdf:type schema:DefinedTerm
115 N6644c372fc4049229347b1d9546ead23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Adenosine
117 rdf:type schema:DefinedTerm
118 N6865129fe1b0468bb5d2c0821a17a49a schema:isbn 978-1-4419-3374-4
119 978-1-4757-3401-0
120 schema:name Hypoxia
121 rdf:type schema:Book
122 N6e1576ff5c9c4bfa85ec73c9e0920d67 rdf:first N3f431365e8b8486f9ff61cef6f8d87d5
123 rdf:rest Nd80be21ad2d149619cef082e5c68edf0
124 N72d2df6fc1d643f9a2413f1193c10861 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Humans
126 rdf:type schema:DefinedTerm
127 N8c7646b030614fa2ba98314575b879d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Hypoxia
129 rdf:type schema:DefinedTerm
130 N9cb52aeb04be4b23a30e7a76d9048d88 schema:familyName Hackett
131 schema:givenName Peter H.
132 rdf:type schema:Person
133 Na4259f9c31e344889d16d42d0a8f833c rdf:first Nf3c98607d85849c1bba3fd66d6ebb6cd
134 rdf:rest N6e1576ff5c9c4bfa85ec73c9e0920d67
135 Naeaf3ef7b12247b8a6c0db92e6e0f0d5 schema:name doi
136 schema:value 10.1007/978-1-4757-3401-0_23
137 rdf:type schema:PropertyValue
138 Nd4d0f44471aa4dcd93cfc7f95ff1ac9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Acute Disease
140 rdf:type schema:DefinedTerm
141 Nd80be21ad2d149619cef082e5c68edf0 rdf:first N9cb52aeb04be4b23a30e7a76d9048d88
142 rdf:rest rdf:nil
143 Ne4ca7740eea64f88a5225b82c759bf52 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Nitric Oxide
145 rdf:type schema:DefinedTerm
146 Nf3c98607d85849c1bba3fd66d6ebb6cd schema:familyName Roach
147 schema:givenName Robert C.
148 rdf:type schema:Person
149 Nf6a31724929f4f098862383ddec8e7da rdf:first sg:person.0753431202.20
150 rdf:rest rdf:nil
151 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
152 schema:name Medical and Health Sciences
153 rdf:type schema:DefinedTerm
154 anzsrc-for:1116 schema:inDefinedTermSet anzsrc-for:
155 schema:name Medical Physiology
156 rdf:type schema:DefinedTerm
157 sg:person.0753431202.20 schema:affiliation grid-institutes:None
158 schema:familyName Marshall
159 schema:givenName Janice M.
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753431202.20
161 rdf:type schema:Person
162 grid-institutes:None schema:alternateName Department of Physiology, The Medical School, Birmingham, UK
163 schema:name Department of Physiology, The Medical School, Birmingham, UK
164 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...