Detoxification of Pertussis Toxin by Site-Directed Mutagenesis View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1989

AUTHORS

S. Cockle , S. Loosmore , K. Radika , G. Zealey , H. Boux , K. Phillips , M. Klein

ABSTRACT

Pertussis toxin (PT) is a major virulence factor of Bordetella pertussis and also an important protective antigen in vaccines against whooping cough. Unfortunately, the chemical treatments normally used to inactivate the toxin can seriously reduce its immunogenicity; moreover, there are concerns that residual traces of active toxin might possibly account for the rare occurrence of vaccination side-effects. Following recent achievements in cloning and sequencing the TOX operon encoding PT (Locht & Keith, 1986; Nicosia et al. , 1986) , the genetic engineering of a PT analogue lacking toxicity but retaining full immunogenicity has become a major goal in the development of improved pertussis vaccines. More... »

PAGES

209-214

Book

TITLE

Immunobiology of Proteins and Peptides V

ISBN

978-1-4757-2048-8
978-1-4757-2046-4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4757-2046-4_20

DOI

http://dx.doi.org/10.1007/978-1-4757-2046-4_20

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003207575


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