Epitope Mimicry by Anti-Idiotype Sequences in Reverse Orientation View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1989

AUTHORS

Dennis W. Metzger , Clayton W. Naeve , Victor H. Van Cleave

ABSTRACT

Antigen mimicry by anti—idiotypic internal images offers one approach to vaccine development and immune modulation. However, the rational design of internal image vaccines and an understanding of idiotypic interactions will depend upon a precise understanding of the rules which govern antigen recognition and of the structural basis for internal image expression. Previous studies using the reovirus hemagglutinin and a synthetic peptide (GAT) identified determinants in antibody internal image variable (V) regions that appeared to match continuous sequences within the respective antigens (Ollier et al., 1985 ; Bruck et al., 1986). More... »

PAGES

187-190

Book

TITLE

Immunobiology of Proteins and Peptides V

ISBN

978-1-4757-2048-8
978-1-4757-2046-4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4757-2046-4_17

DOI

http://dx.doi.org/10.1007/978-1-4757-2046-4_17

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001549253


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