Hexadecylphosphocholine (D-18506): A New Phospholipid with Highly Selective Antitumor Activity View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1990

AUTHORS

W. Schumacher , J. Stekar , P. Hilgard , J. Engel , H. Eibl , C. Unger

ABSTRACT

Ether lipids have several biological functions as important components of mammalian cells. Considerable interest has recently focussed on the “platelet activating factor” (PAF; 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine), which seems to be of pathogenic importance in the mediation of allergic and inflammatory reactions. A number of analogs of PAF whithout platelet aggregating activity are cytotoxic for a variety of cell types3. Racemic 1-octadecyl-2-methyl-glycero-3-phosphocholine (Et-18-0CH3; INN: Edelfosine) was the prototype in this class of new anti-cancer agents to undergo preclinical evaluation. More... »

PAGES

287-290

References to SciGraph publications

Book

TITLE

Phospholipids

ISBN

978-1-4757-1366-4
978-1-4757-1364-0

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4757-1364-0_27

DOI

http://dx.doi.org/10.1007/978-1-4757-1364-0_27

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028870801


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