Protein Kinase C — Structural Studies View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1988

AUTHORS

Peter J. Parker , Richard Marais , Mona Bajaj , Fiona Mitchell , Peter King , Sue Young , Axel Ullrich , Silvia Stabel

ABSTRACT

Protein kinase C was first reported by Nishizuka and colleagues. This group identified a histone kinase activity that was irreversibly activated by mM concentrations of Ca2+ (Takai et al., 1977), an effect shown to be due to proteolysis of the holoenzyme by contaminating Ca2+-activated neutral protease (Inoue et al., 1977). Reversible activation was subsequently shown to occur in response to Ca2+ (~10-5M) and anionic phospholipid, phosphatidylserine being the most effective (Takai et al., 1979). Furthermore, activation could be effected at physiological Ca2+ concentrations (~10-6M) if the neutral lipid diacylglycerol was also present (Kishimoto et al., 1980). These characteristics of protein kinase C have led to the operational definition of the enzyme as a Ca2+/phospholipid dependent protein kinase. More... »

PAGES

417-426

Book

TITLE

Advances in Post-Translational Modifications of Proteins and Aging

ISBN

978-1-4684-9044-2
978-1-4684-9042-8

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4684-9042-8_33

DOI

http://dx.doi.org/10.1007/978-1-4684-9042-8_33

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008313805


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