Acetylcholine Induced Antinociception: Comparisons to Opiate Analgesia View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1981

AUTHORS

N. W. Pedigo , W. L. Dewey

ABSTRACT

The ability of a number of cholinomimetic drugs to inhibit nociceptive responses in several animal species is well documented. Cholinomimetic agents which have shown antinociceptive activity in a variety of tests include the following: oxotremorine (16,19,26,32, 37,38,42), tremorine (7), arecoline (23,25,29,37,44), pilocarpine (10,25,29) and physostigmine (10,20,22,28,34,42,44,49). The specific central muscarinic mediation of these antinociceptive effects is agreed upon by most authors (10,25,28,37). Cholinomimetic drugs also potentiate narcotic analgesia in laboratory animals (1,26,28, 29,42,46,56) and in man (8,15,40,50,54). However, the relationship of cholinomimetic to narcotic analgesia remains unclear. Both classes of drugs demonstrate antinociceptive activity in similar tests and tolerance to each has been noted (see 48,55; also 10,26, 34). Significant cross-tolerance between narcotics and cholinomimetics has not been observed. Investigations into the possible inhibition of cholinergic antinociception by narcotic antagonists (7,18,20,26-28,42) and, conversely, the inhibition of narcotic analgesia by muscarinic receptor blockers (3,7,8,10,27-29,56) have yielded mixed results. More... »

PAGES

795-807

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4684-8643-8_78

DOI

http://dx.doi.org/10.1007/978-1-4684-8643-8_78

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012643098


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