Prostacyclin and its Analogues for the Therapy of Thromboembolic Disorders View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1984

AUTHORS

B. J. R. Whittle , S. Moncada

ABSTRACT

The discovery that blood vessels synthesize and release an unstable arachidonic acid metabolite, prostacyclin, which is a potent vasodilator and inhibitor of platelet aggregation (Moncada, Gryglewski, Bunting and Vane, 1976) has implicated this prostanoid as an important factor in the regulation of vascular tone and haemostasis (Moncada and Vane, 1979). This bicyclic enol-ether is derived from the fatty acid precursor arachidonic acid via the unstable endoper-oxide intermediates. These are transformed by the action of an enzyme system, prostacyclin synthetase, which is located predominantly in vascular endothelium. It has become apparent that prostacyclin has many potential clinical applications for the management of thromboembolic disorders (Table 1). More... »

PAGES

193-209

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4684-8616-2_20

DOI

http://dx.doi.org/10.1007/978-1-4684-8616-2_20

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046070648

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6364707


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