Specific Inhibitors as Probes into the Biosynthesis And Metabolism of Aromatic Amino Acids View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1986

AUTHORS

Nikolaus Amrhein

ABSTRACT

Inhibitors of enzymic and metabolic processes are invaluable tools in biochemical and physiological research, and their application as drugs or pesticides ranges from medicine to agriculture. The information one can extract from their judicious use depends, on the one hand, on the complexity of the system to which they are applied and, on the other hand, on their selectivity for a given target, as well as on their access to this target. Accessibility in this context is meant to include the arrival of the inhibitor at its target site in a state in which it is capable of exerting its inhibitory action. It is obvious that the chances for selectivity of a given inhibitor decrease with the increasing complexity of a system as measured, for example, by the number of enzymic reactions involved and the degree of their interaction and interdependence in the metabolic network of a cell. To illustrate this point, α-aminooxy acetic acid (AOA) is a fairly potent inhibitor of the biosynthesis of phenylpropanoid compounds and has been used in complementation experiments to study the biosynthesis of cyanidin in buckwheat.1 More... »

PAGES

83-117

Book

TITLE

The Shikimic Acid Pathway

ISBN

978-1-4684-8058-0
978-1-4684-8056-6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4684-8056-6_4

DOI

http://dx.doi.org/10.1007/978-1-4684-8056-6_4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010267980


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Lehrstuhl f\u00fcr Pflanzenphysiologie, Ruhr-Universit\u00e4t Bochum, D-4630, Bochum, Federal Republic of Germany", 
          "id": "http://www.grid.ac/institutes/grid.5570.7", 
          "name": [
            "Lehrstuhl f\u00fcr Pflanzenphysiologie, Ruhr-Universit\u00e4t Bochum, D-4630, Bochum, Federal Republic of Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Amrhein", 
        "givenName": "Nikolaus", 
        "id": "sg:person.0663624415.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663624415.92"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1986", 
    "datePublishedReg": "1986-01-01", 
    "description": "Inhibitors of enzymic and metabolic processes are invaluable tools in biochemical and physiological research, and their application as drugs or pesticides ranges from medicine to agriculture. The information one can extract from their judicious use depends, on the one hand, on the complexity of the system to which they are applied and, on the other hand, on their selectivity for a given target, as well as on their access to this target. Accessibility in this context is meant to include the arrival of the inhibitor at its target site in a state in which it is capable of exerting its inhibitory action. It is obvious that the chances for selectivity of a given inhibitor decrease with the increasing complexity of a system as measured, for example, by the number of enzymic reactions involved and the degree of their interaction and interdependence in the metabolic network of a cell. To illustrate this point, \u03b1-aminooxy acetic acid (AOA) is a fairly potent inhibitor of the biosynthesis of phenylpropanoid compounds and has been used in complementation experiments to study the biosynthesis of cyanidin in buckwheat.1", 
    "editor": [
      {
        "familyName": "Conn", 
        "givenName": "Eric E.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-1-4684-8056-6_4", 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-1-4684-8058-0", 
        "978-1-4684-8056-6"
      ], 
      "name": "The Shikimic Acid Pathway", 
      "type": "Book"
    }, 
    "keywords": [
      "\u03b1-aminooxy acetic acid", 
      "complementation experiments", 
      "aromatic amino acids", 
      "metabolic networks", 
      "phenylpropanoid compounds", 
      "metabolic processes", 
      "specific inhibitor", 
      "amino acids", 
      "biosynthesis", 
      "target site", 
      "physiological research", 
      "inhibitor decreases", 
      "potent inhibitor", 
      "inhibitors", 
      "invaluable tool", 
      "enzymic reaction", 
      "acetic acid", 
      "target", 
      "selectivity", 
      "acid", 
      "metabolism", 
      "buckwheat", 
      "cells", 
      "inhibitory action", 
      "pesticides", 
      "sites", 
      "cyanidin", 
      "agriculture", 
      "compounds", 
      "probe", 
      "reaction", 
      "interaction", 
      "accessibility", 
      "action", 
      "number", 
      "complexity", 
      "process", 
      "experiments", 
      "applications", 
      "tool", 
      "system", 
      "drugs", 
      "decrease", 
      "hand", 
      "medicine", 
      "information", 
      "state", 
      "network", 
      "chance", 
      "degree", 
      "example", 
      "context", 
      "interdependence", 
      "judicious use", 
      "use", 
      "research", 
      "arrival", 
      "point", 
      "access"
    ], 
    "name": "Specific Inhibitors as Probes into the Biosynthesis And Metabolism of Aromatic Amino Acids", 
    "pagination": "83-117", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1010267980"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-1-4684-8056-6_4"
        ]
      }
    ], 
    "publisher": {
      "name": "Springer Nature", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-1-4684-8056-6_4", 
      "https://app.dimensions.ai/details/publication/pub.1010267980"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2022-12-01T06:46", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/chapter/chapter_120.jsonl", 
    "type": "Chapter", 
    "url": "https://doi.org/10.1007/978-1-4684-8056-6_4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4684-8056-6_4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4684-8056-6_4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4684-8056-6_4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4684-8056-6_4'


 

This table displays all metadata directly associated to this object as RDF triples.

118 TRIPLES      22 PREDICATES      84 URIs      77 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-1-4684-8056-6_4 schema:about anzsrc-for:06
2 anzsrc-for:0601
3 schema:author Nf1b88e12200e4dd794d283d3a625eed4
4 schema:datePublished 1986
5 schema:datePublishedReg 1986-01-01
6 schema:description Inhibitors of enzymic and metabolic processes are invaluable tools in biochemical and physiological research, and their application as drugs or pesticides ranges from medicine to agriculture. The information one can extract from their judicious use depends, on the one hand, on the complexity of the system to which they are applied and, on the other hand, on their selectivity for a given target, as well as on their access to this target. Accessibility in this context is meant to include the arrival of the inhibitor at its target site in a state in which it is capable of exerting its inhibitory action. It is obvious that the chances for selectivity of a given inhibitor decrease with the increasing complexity of a system as measured, for example, by the number of enzymic reactions involved and the degree of their interaction and interdependence in the metabolic network of a cell. To illustrate this point, α-aminooxy acetic acid (AOA) is a fairly potent inhibitor of the biosynthesis of phenylpropanoid compounds and has been used in complementation experiments to study the biosynthesis of cyanidin in buckwheat.1
7 schema:editor N5b6d8b6cff1745bc901d28ad886fe770
8 schema:genre chapter
9 schema:isAccessibleForFree false
10 schema:isPartOf Na44e9af31e464543aff29f783140db2a
11 schema:keywords access
12 accessibility
13 acetic acid
14 acid
15 action
16 agriculture
17 amino acids
18 applications
19 aromatic amino acids
20 arrival
21 biosynthesis
22 buckwheat
23 cells
24 chance
25 complementation experiments
26 complexity
27 compounds
28 context
29 cyanidin
30 decrease
31 degree
32 drugs
33 enzymic reaction
34 example
35 experiments
36 hand
37 information
38 inhibitor decreases
39 inhibitors
40 inhibitory action
41 interaction
42 interdependence
43 invaluable tool
44 judicious use
45 medicine
46 metabolic networks
47 metabolic processes
48 metabolism
49 network
50 number
51 pesticides
52 phenylpropanoid compounds
53 physiological research
54 point
55 potent inhibitor
56 probe
57 process
58 reaction
59 research
60 selectivity
61 sites
62 specific inhibitor
63 state
64 system
65 target
66 target site
67 tool
68 use
69 α-aminooxy acetic acid
70 schema:name Specific Inhibitors as Probes into the Biosynthesis And Metabolism of Aromatic Amino Acids
71 schema:pagination 83-117
72 schema:productId N628380b1ad1b4afaadfcdf03099c547e
73 Need0259055f64e4890e31f32a7285a54
74 schema:publisher N236d555c6fd0478f826d57c00976c043
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010267980
76 https://doi.org/10.1007/978-1-4684-8056-6_4
77 schema:sdDatePublished 2022-12-01T06:46
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher Nf7b31f791303461dadd8984c294e09e3
80 schema:url https://doi.org/10.1007/978-1-4684-8056-6_4
81 sgo:license sg:explorer/license/
82 sgo:sdDataset chapters
83 rdf:type schema:Chapter
84 N187d5e60b2ce4e6e8525cc059f4411e0 schema:familyName Conn
85 schema:givenName Eric E.
86 rdf:type schema:Person
87 N236d555c6fd0478f826d57c00976c043 schema:name Springer Nature
88 rdf:type schema:Organisation
89 N5b6d8b6cff1745bc901d28ad886fe770 rdf:first N187d5e60b2ce4e6e8525cc059f4411e0
90 rdf:rest rdf:nil
91 N628380b1ad1b4afaadfcdf03099c547e schema:name doi
92 schema:value 10.1007/978-1-4684-8056-6_4
93 rdf:type schema:PropertyValue
94 Na44e9af31e464543aff29f783140db2a schema:isbn 978-1-4684-8056-6
95 978-1-4684-8058-0
96 schema:name The Shikimic Acid Pathway
97 rdf:type schema:Book
98 Need0259055f64e4890e31f32a7285a54 schema:name dimensions_id
99 schema:value pub.1010267980
100 rdf:type schema:PropertyValue
101 Nf1b88e12200e4dd794d283d3a625eed4 rdf:first sg:person.0663624415.92
102 rdf:rest rdf:nil
103 Nf7b31f791303461dadd8984c294e09e3 schema:name Springer Nature - SN SciGraph project
104 rdf:type schema:Organization
105 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
106 schema:name Biological Sciences
107 rdf:type schema:DefinedTerm
108 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
109 schema:name Biochemistry and Cell Biology
110 rdf:type schema:DefinedTerm
111 sg:person.0663624415.92 schema:affiliation grid-institutes:grid.5570.7
112 schema:familyName Amrhein
113 schema:givenName Nikolaus
114 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663624415.92
115 rdf:type schema:Person
116 grid-institutes:grid.5570.7 schema:alternateName Lehrstuhl für Pflanzenphysiologie, Ruhr-Universität Bochum, D-4630, Bochum, Federal Republic of Germany
117 schema:name Lehrstuhl für Pflanzenphysiologie, Ruhr-Universität Bochum, D-4630, Bochum, Federal Republic of Germany
118 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...