Ontology type: schema:Chapter
1984
AUTHORSRichard P. Wennberg , A. J. Hance , Jorgen Jacobsen
ABSTRACTSeveral recent studies have created considerable confusion about the cause and prevention of kernicterus.1,2,3 In 1982, Levine et al1 demonstrated in rats that “kernicterus” could be produced by osmotic opening of the blood brain barrier. Using a technique described by Rapoport et al,4 a hypertonic solution of arabinose was infused into one carotid artery, producing a temporary osmotically induced disruption of the blood brain barrier in the ipsilateral hemisphere. Subsequent intravenous infusion of bilirubin resulted in yellow staining of the affected region. Levine proposed that movement of albumin bound bilirubin across a disrupted barrier was the principal cause of kernicterus, and presented this as “an alternative hypothesis” to the “free bilirubin theory.” However, he provided no evidence that the yellow staining produced brain damage, either by histological examination or behavioral consequences. These observations, together with other studies which failed to confirm any predictive indices for kernicterus in premature infants,2,3 prompted Lucey5 to editorialize that current concepts of the pathogenesis of kernicterus should be abandoned in search for a “more attractive hypothesis.” More... »
PAGES35-43
Neonatal Jaundice
ISBN
978-1-4684-7519-7
978-1-4684-7517-3
http://scigraph.springernature.com/pub.10.1007/978-1-4684-7517-3_4
DOIhttp://dx.doi.org/10.1007/978-1-4684-7517-3_4
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1025142901
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Neurosciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "School of Medicine, University of California, Davis, 95616, Davis, CA, USA",
"id": "http://www.grid.ac/institutes/grid.27860.3b",
"name": [
"School of Medicine, University of California, Davis, 95616, Davis, CA, USA"
],
"type": "Organization"
},
"familyName": "Wennberg",
"givenName": "Richard P.",
"id": "sg:person.070063300.96",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.070063300.96"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "School of Medicine, University of California, Davis, 95616, Davis, CA, USA",
"id": "http://www.grid.ac/institutes/grid.27860.3b",
"name": [
"School of Medicine, University of California, Davis, 95616, Davis, CA, USA"
],
"type": "Organization"
},
"familyName": "Hance",
"givenName": "A. J.",
"id": "sg:person.01075454535.89",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075454535.89"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "School of Medicine, University of California, Davis, 95616, Davis, CA, USA",
"id": "http://www.grid.ac/institutes/grid.27860.3b",
"name": [
"School of Medicine, University of California, Davis, 95616, Davis, CA, USA"
],
"type": "Organization"
},
"familyName": "Jacobsen",
"givenName": "Jorgen",
"type": "Person"
}
],
"datePublished": "1984",
"datePublishedReg": "1984-01-01",
"description": "Several recent studies have created considerable confusion about the cause and prevention of kernicterus.1,2,3 In 1982, Levine et al1 demonstrated in rats that \u201ckernicterus\u201d could be produced by osmotic opening of the blood brain barrier. Using a technique described by Rapoport et al,4 a hypertonic solution of arabinose was infused into one carotid artery, producing a temporary osmotically induced disruption of the blood brain barrier in the ipsilateral hemisphere. Subsequent intravenous infusion of bilirubin resulted in yellow staining of the affected region. Levine proposed that movement of albumin bound bilirubin across a disrupted barrier was the principal cause of kernicterus, and presented this as \u201can alternative hypothesis\u201d to the \u201cfree bilirubin theory.\u201d However, he provided no evidence that the yellow staining produced brain damage, either by histological examination or behavioral consequences. These observations, together with other studies which failed to confirm any predictive indices for kernicterus in premature infants,2,3 prompted Lucey5 to editorialize that current concepts of the pathogenesis of kernicterus should be abandoned in search for a \u201cmore attractive hypothesis.\u201d",
"editor": [
{
"familyName": "Rubaltelli",
"givenName": "Firmino F.",
"type": "Person"
},
{
"familyName": "Jori",
"givenName": "Giulio",
"type": "Person"
}
],
"genre": "chapter",
"id": "sg:pub.10.1007/978-1-4684-7517-3_4",
"inLanguage": "en",
"isAccessibleForFree": false,
"isPartOf": {
"isbn": [
"978-1-4684-7519-7",
"978-1-4684-7517-3"
],
"name": "Neonatal Jaundice",
"type": "Book"
},
"keywords": [
"blood-brain barrier",
"brain barrier",
"yellow staining",
"prevention of kernicterus",
"subsequent intravenous infusion",
"acute bilirubin neurotoxicity",
"movement of albumin",
"pathogenesis of kernicterus",
"ipsilateral hemisphere",
"osmotic opening",
"intravenous infusion",
"brain damage",
"carotid artery",
"histological examination",
"kernicterus",
"bilirubin neurotoxicity",
"serum binding",
"predictive index",
"current concepts",
"hypertonic solutions",
"bilirubin",
"principal cause",
"behavioral consequences",
"attractive hypothesis",
"et al1",
"staining",
"Recent studies",
"cause",
"affected region",
"artery",
"infusion",
"pathogenesis",
"neurotoxicity",
"rats",
"prevention",
"barriers",
"study",
"examination",
"albumin",
"considerable confusion",
"hypothesis",
"damage",
"disruption",
"evidence",
"index",
"hemisphere",
"binding",
"confusion",
"search",
"consequences",
"development",
"importance",
"Al1",
"opening",
"movement",
"alternative hypothesis",
"observations",
"region",
"technique",
"et",
"Levine",
"arabinose",
"concept",
"solution",
"theory"
],
"name": "The Importance of Serum Binding and the Blood Brain Barrier in the Development of Acute Bilirubin Neurotoxicity",
"pagination": "35-43",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1025142901"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/978-1-4684-7517-3_4"
]
}
],
"publisher": {
"name": "Springer Nature",
"type": "Organisation"
},
"sameAs": [
"https://doi.org/10.1007/978-1-4684-7517-3_4",
"https://app.dimensions.ai/details/publication/pub.1025142901"
],
"sdDataset": "chapters",
"sdDatePublished": "2022-05-20T07:45",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/chapter/chapter_283.jsonl",
"type": "Chapter",
"url": "https://doi.org/10.1007/978-1-4684-7517-3_4"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4684-7517-3_4'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4684-7517-3_4'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4684-7517-3_4'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4684-7517-3_4'
This table displays all metadata directly associated to this object as RDF triples.
143 TRIPLES
23 PREDICATES
91 URIs
84 LITERALS
7 BLANK NODES
Subject | Predicate | Object | |
---|---|---|---|
1 | sg:pub.10.1007/978-1-4684-7517-3_4 | schema:about | anzsrc-for:11 |
2 | ″ | ″ | anzsrc-for:1109 |
3 | ″ | schema:author | Nff87e4c7347c4cfba3f692226da8f0bd |
4 | ″ | schema:datePublished | 1984 |
5 | ″ | schema:datePublishedReg | 1984-01-01 |
6 | ″ | schema:description | Several recent studies have created considerable confusion about the cause and prevention of kernicterus.1,2,3 In 1982, Levine et al1 demonstrated in rats that “kernicterus” could be produced by osmotic opening of the blood brain barrier. Using a technique described by Rapoport et al,4 a hypertonic solution of arabinose was infused into one carotid artery, producing a temporary osmotically induced disruption of the blood brain barrier in the ipsilateral hemisphere. Subsequent intravenous infusion of bilirubin resulted in yellow staining of the affected region. Levine proposed that movement of albumin bound bilirubin across a disrupted barrier was the principal cause of kernicterus, and presented this as “an alternative hypothesis” to the “free bilirubin theory.” However, he provided no evidence that the yellow staining produced brain damage, either by histological examination or behavioral consequences. These observations, together with other studies which failed to confirm any predictive indices for kernicterus in premature infants,2,3 prompted Lucey5 to editorialize that current concepts of the pathogenesis of kernicterus should be abandoned in search for a “more attractive hypothesis.” |
7 | ″ | schema:editor | N069985e3daea4bfdb22306e2afe2bfb6 |
8 | ″ | schema:genre | chapter |
9 | ″ | schema:inLanguage | en |
10 | ″ | schema:isAccessibleForFree | false |
11 | ″ | schema:isPartOf | N5ce4b6ccab6b4c9f846d38dc3eb24494 |
12 | ″ | schema:keywords | Al1 |
13 | ″ | ″ | Levine |
14 | ″ | ″ | Recent studies |
15 | ″ | ″ | acute bilirubin neurotoxicity |
16 | ″ | ″ | affected region |
17 | ″ | ″ | albumin |
18 | ″ | ″ | alternative hypothesis |
19 | ″ | ″ | arabinose |
20 | ″ | ″ | artery |
21 | ″ | ″ | attractive hypothesis |
22 | ″ | ″ | barriers |
23 | ″ | ″ | behavioral consequences |
24 | ″ | ″ | bilirubin |
25 | ″ | ″ | bilirubin neurotoxicity |
26 | ″ | ″ | binding |
27 | ″ | ″ | blood-brain barrier |
28 | ″ | ″ | brain barrier |
29 | ″ | ″ | brain damage |
30 | ″ | ″ | carotid artery |
31 | ″ | ″ | cause |
32 | ″ | ″ | concept |
33 | ″ | ″ | confusion |
34 | ″ | ″ | consequences |
35 | ″ | ″ | considerable confusion |
36 | ″ | ″ | current concepts |
37 | ″ | ″ | damage |
38 | ″ | ″ | development |
39 | ″ | ″ | disruption |
40 | ″ | ″ | et |
41 | ″ | ″ | et al1 |
42 | ″ | ″ | evidence |
43 | ″ | ″ | examination |
44 | ″ | ″ | hemisphere |
45 | ″ | ″ | histological examination |
46 | ″ | ″ | hypertonic solutions |
47 | ″ | ″ | hypothesis |
48 | ″ | ″ | importance |
49 | ″ | ″ | index |
50 | ″ | ″ | infusion |
51 | ″ | ″ | intravenous infusion |
52 | ″ | ″ | ipsilateral hemisphere |
53 | ″ | ″ | kernicterus |
54 | ″ | ″ | movement |
55 | ″ | ″ | movement of albumin |
56 | ″ | ″ | neurotoxicity |
57 | ″ | ″ | observations |
58 | ″ | ″ | opening |
59 | ″ | ″ | osmotic opening |
60 | ″ | ″ | pathogenesis |
61 | ″ | ″ | pathogenesis of kernicterus |
62 | ″ | ″ | predictive index |
63 | ″ | ″ | prevention |
64 | ″ | ″ | prevention of kernicterus |
65 | ″ | ″ | principal cause |
66 | ″ | ″ | rats |
67 | ″ | ″ | region |
68 | ″ | ″ | search |
69 | ″ | ″ | serum binding |
70 | ″ | ″ | solution |
71 | ″ | ″ | staining |
72 | ″ | ″ | study |
73 | ″ | ″ | subsequent intravenous infusion |
74 | ″ | ″ | technique |
75 | ″ | ″ | theory |
76 | ″ | ″ | yellow staining |
77 | ″ | schema:name | The Importance of Serum Binding and the Blood Brain Barrier in the Development of Acute Bilirubin Neurotoxicity |
78 | ″ | schema:pagination | 35-43 |
79 | ″ | schema:productId | N56387448757d405cbde4bc3e51a58e4b |
80 | ″ | ″ | Na0b88f2679804ecbafc242f702f0893e |
81 | ″ | schema:publisher | N3e3ca581afa845688519dc1d384826b8 |
82 | ″ | schema:sameAs | https://app.dimensions.ai/details/publication/pub.1025142901 |
83 | ″ | ″ | https://doi.org/10.1007/978-1-4684-7517-3_4 |
84 | ″ | schema:sdDatePublished | 2022-05-20T07:45 |
85 | ″ | schema:sdLicense | https://scigraph.springernature.com/explorer/license/ |
86 | ″ | schema:sdPublisher | Nb5df7f05d5a443608f4eb24bd39ec914 |
87 | ″ | schema:url | https://doi.org/10.1007/978-1-4684-7517-3_4 |
88 | ″ | sgo:license | sg:explorer/license/ |
89 | ″ | sgo:sdDataset | chapters |
90 | ″ | rdf:type | schema:Chapter |
91 | N069985e3daea4bfdb22306e2afe2bfb6 | rdf:first | Neaf3247221e04d3ba1319cfa51879a4c |
92 | ″ | rdf:rest | N79b5917a66b24c468c63e6ae92cc3a61 |
93 | N3e3ca581afa845688519dc1d384826b8 | schema:name | Springer Nature |
94 | ″ | rdf:type | schema:Organisation |
95 | N56387448757d405cbde4bc3e51a58e4b | schema:name | doi |
96 | ″ | schema:value | 10.1007/978-1-4684-7517-3_4 |
97 | ″ | rdf:type | schema:PropertyValue |
98 | N5ce4b6ccab6b4c9f846d38dc3eb24494 | schema:isbn | 978-1-4684-7517-3 |
99 | ″ | ″ | 978-1-4684-7519-7 |
100 | ″ | schema:name | Neonatal Jaundice |
101 | ″ | rdf:type | schema:Book |
102 | N72b3b456fa29419ea02d88078ca51590 | schema:familyName | Jori |
103 | ″ | schema:givenName | Giulio |
104 | ″ | rdf:type | schema:Person |
105 | N79b5917a66b24c468c63e6ae92cc3a61 | rdf:first | N72b3b456fa29419ea02d88078ca51590 |
106 | ″ | rdf:rest | rdf:nil |
107 | Na0b88f2679804ecbafc242f702f0893e | schema:name | dimensions_id |
108 | ″ | schema:value | pub.1025142901 |
109 | ″ | rdf:type | schema:PropertyValue |
110 | Nb5df7f05d5a443608f4eb24bd39ec914 | schema:name | Springer Nature - SN SciGraph project |
111 | ″ | rdf:type | schema:Organization |
112 | Ncff9e499e1da4a1fba85cdaac1b912f5 | rdf:first | Ndc1c9f7130424a76819711c33cc36d96 |
113 | ″ | rdf:rest | rdf:nil |
114 | Ndc1c9f7130424a76819711c33cc36d96 | schema:affiliation | grid-institutes:grid.27860.3b |
115 | ″ | schema:familyName | Jacobsen |
116 | ″ | schema:givenName | Jorgen |
117 | ″ | rdf:type | schema:Person |
118 | Ne010a8cd6b5048c68680a4dd01868d19 | rdf:first | sg:person.01075454535.89 |
119 | ″ | rdf:rest | Ncff9e499e1da4a1fba85cdaac1b912f5 |
120 | Neaf3247221e04d3ba1319cfa51879a4c | schema:familyName | Rubaltelli |
121 | ″ | schema:givenName | Firmino F. |
122 | ″ | rdf:type | schema:Person |
123 | Nff87e4c7347c4cfba3f692226da8f0bd | rdf:first | sg:person.070063300.96 |
124 | ″ | rdf:rest | Ne010a8cd6b5048c68680a4dd01868d19 |
125 | anzsrc-for:11 | schema:inDefinedTermSet | anzsrc-for: |
126 | ″ | schema:name | Medical and Health Sciences |
127 | ″ | rdf:type | schema:DefinedTerm |
128 | anzsrc-for:1109 | schema:inDefinedTermSet | anzsrc-for: |
129 | ″ | schema:name | Neurosciences |
130 | ″ | rdf:type | schema:DefinedTerm |
131 | sg:person.01075454535.89 | schema:affiliation | grid-institutes:grid.27860.3b |
132 | ″ | schema:familyName | Hance |
133 | ″ | schema:givenName | A. J. |
134 | ″ | schema:sameAs | https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075454535.89 |
135 | ″ | rdf:type | schema:Person |
136 | sg:person.070063300.96 | schema:affiliation | grid-institutes:grid.27860.3b |
137 | ″ | schema:familyName | Wennberg |
138 | ″ | schema:givenName | Richard P. |
139 | ″ | schema:sameAs | https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.070063300.96 |
140 | ″ | rdf:type | schema:Person |
141 | grid-institutes:grid.27860.3b | schema:alternateName | School of Medicine, University of California, Davis, 95616, Davis, CA, USA |
142 | ″ | schema:name | School of Medicine, University of California, Davis, 95616, Davis, CA, USA |
143 | ″ | rdf:type | schema:Organization |