Transcriptional Regulation by Heavy Metals, Exemplified at the Metallothionein Genes View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1995

AUTHORS

Rainer Heuchel , Freddy Radtke , Walter Schaffner

ABSTRACT

Seventeen of the thirty elements known to be essential for life are metals (Cotton and Wilkinson, 1980). They can function as structural or catalytic components of bioorganic molecules or even as signal transducers. (Lippard, 1993). The so-called transition metals are found in the groups HIB to IIB of the periodic system. Of these, zinc (Group IIB) is the most widely used in living systems. In 1869 it was discovered that zinc is an essential trace element for higher organisms, and in 1940, it was the first trace element to be recognized as a component of an enzyme, namely carbonic anhydrase (Raulin, 1869; Keilin and Mann, 1940). To date, there are more than 300 enzymes known to require zinc for proper functioning (Vallee and Auld, 1990). Pathological zinc deficiency, due to greatly reduced intestinal zinc uptake as in the recessive, autosomal disorder Acrodermatitis enteropathica, leads to death unless treated by high oral zinc doses (Vallee and Falchuk, 1993). Among the zinc dependent enzymes several are involved in nucleic acid metabolism such as the prokaryotic and eukaryotic RNA polymerases (Vallee and Falchuk, 1993). It has been discovered only recently that zinc is also an integral constituent of proteins that regulate the activity of eukaryotic RNA polymerases. More... »

PAGES

206-240

Book

TITLE

Inducible Gene Expression, Volume 1

ISBN

978-1-4684-6842-7
978-1-4684-6840-3

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4684-6840-3_7

DOI

http://dx.doi.org/10.1007/978-1-4684-6840-3_7

DIMENSIONS

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