Chemistry of Tracers for Positron Emission Tomography View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1993

AUTHORS

Robert F. Dannals , Hayden T. Ravert , Alan A. Wilson

ABSTRACT

There are hundreds of naturally occurring and artificial radionuclides; however, only a small number have found use in biomedical research. Of this limited number, a select few have been used to study biochemistry and pharmacology in vivo with emission tomography. Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) offer biomedical researchers unique opportunities for studying a wide variety of biochemical and pharmacological interactions in living man. While SPECT offers the advantages of widespread availability of instrumentation and relative low cost of radionuclides (e.g., Technetium-99m and Iodine-123), PET has the distinct advantages of quantitative instrumentation and versatile chemistry of radionuclides (especially, Oxygen-15, Nitrogen-13, Carbon-11, and Fluorine-18). This chapter will focus primarily on these four radioisotopes for PET and highlight certain aspects of the radiochemistry involved in the preparation of tracers for PET studies. More... »

PAGES

55-74

References to SciGraph publications

  • 1988-05. PET measurement of D2 and S2 receptor binding of 3-N-([2′-18F]fluoroethyl)spiperone in baboon brain in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • Book

    TITLE

    Nuclear Imaging in Drug Discovery, Development, and Approval

    ISBN

    978-1-4684-6810-6
    978-1-4684-6808-3

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-4684-6808-3_4

    DOI

    http://dx.doi.org/10.1007/978-1-4684-6808-3_4

    DIMENSIONS

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    40 schema:description There are hundreds of naturally occurring and artificial radionuclides; however, only a small number have found use in biomedical research. Of this limited number, a select few have been used to study biochemistry and pharmacology in vivo with emission tomography. Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) offer biomedical researchers unique opportunities for studying a wide variety of biochemical and pharmacological interactions in living man. While SPECT offers the advantages of widespread availability of instrumentation and relative low cost of radionuclides (e.g., Technetium-99m and Iodine-123), PET has the distinct advantages of quantitative instrumentation and versatile chemistry of radionuclides (especially, Oxygen-15, Nitrogen-13, Carbon-11, and Fluorine-18). This chapter will focus primarily on these four radioisotopes for PET and highlight certain aspects of the radiochemistry involved in the preparation of tracers for PET studies.
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