Distinct Kinetic Properties of Cardiac Myosin Isoforms Revealed by In Vitro Studies View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1998

AUTHORS

Seiryo Sugiura , Naoshi Kobayakawa , Hideo Fujita , Shin-ichi Momomura , Shigeru Chaen , Haruo Sugi

ABSTRACT

To clarify the physiological significance of myosin isoform redistribution in cardiac adaptation process, we compared the kinetic property of the two cardiac myosin isoforms using in vitro motility assay techniques. Cardiac myosin isoforms V1 and V3 were obtained from ventricular muscle of young rats and hypothyroid rats respectively. On each of these myosin isoforms fixed on a glass coverslip, fluorescently labeled actin filaments were made to slide in the presence of ATP. To measure the force generated by actomyosin interaction, a small latex bead was attached to the barbed end of an actin filament and the bead was captured by the laser optical trap installed in a microscope. The force was determined from the distance between the bead and the trap positions under either auxotonic or isometric conditions. The time-averaged force generated by multiple cross-bridges did not differ significantly between the two isoforms. On the other hand, the unitary force measurement revealed the same level of amplitude but a longer duration for V3 isoform. The same level of time-averaged force is in agreement with not only our previous finding but the results of maximum force measurement in muscle preparations. The difference in kinetic characteristics of the two isoforms could account for the difference in economy of force development and the basis for cardiac adaptation mechanism. More... »

PAGES

125-130

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4684-6039-1_15

DOI

http://dx.doi.org/10.1007/978-1-4684-6039-1_15

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035066345

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9889822


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heart", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kinetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardial Contraction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myosins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Isoforms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Wistar", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The Second Department of Internal Medicine School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "The Second Department of Internal Medicine School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sugiura", 
        "givenName": "Seiryo", 
        "id": "sg:person.01277502614.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277502614.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Second Department of Internal Medicine School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "The Second Department of Internal Medicine School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kobayakawa", 
        "givenName": "Naoshi", 
        "id": "sg:person.01211752724.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211752724.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Second Department of Internal Medicine School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "The Second Department of Internal Medicine School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fujita", 
        "givenName": "Hideo", 
        "id": "sg:person.01122202105.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122202105.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Second Department of Internal Medicine School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "The Second Department of Internal Medicine School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Momomura", 
        "givenName": "Shin-ichi", 
        "id": "sg:person.01242732453.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242732453.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physiology, Teikyo University School of Medicine, Itabashi-ku, Tokyo 173, Japan", 
          "id": "http://www.grid.ac/institutes/grid.264706.1", 
          "name": [
            "Department of Physiology, Teikyo University School of Medicine, Itabashi-ku, Tokyo 173, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chaen", 
        "givenName": "Shigeru", 
        "id": "sg:person.0763036400.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763036400.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physiology, Teikyo University School of Medicine, Itabashi-ku, Tokyo 173, Japan", 
          "id": "http://www.grid.ac/institutes/grid.264706.1", 
          "name": [
            "Department of Physiology, Teikyo University School of Medicine, Itabashi-ku, Tokyo 173, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sugi", 
        "givenName": "Haruo", 
        "id": "sg:person.01050463112.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050463112.62"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1998", 
    "datePublishedReg": "1998-01-01", 
    "description": "To clarify the physiological significance of myosin isoform redistribution in cardiac adaptation process, we compared the kinetic property of the two cardiac myosin isoforms using in vitro motility assay techniques. Cardiac myosin isoforms V1 and V3 were obtained from ventricular muscle of young rats and hypothyroid rats respectively. On each of these myosin isoforms fixed on a glass coverslip, fluorescently labeled actin filaments were made to slide in the presence of ATP. To measure the force generated by actomyosin interaction, a small latex bead was attached to the barbed end of an actin filament and the bead was captured by the laser optical trap installed in a microscope. The force was determined from the distance between the bead and the trap positions under either auxotonic or isometric conditions. The time-averaged force generated by multiple cross-bridges did not differ significantly between the two isoforms. On the other hand, the unitary force measurement revealed the same level of amplitude but a longer duration for V3 isoform. The same level of time-averaged force is in agreement with not only our previous finding but the results of maximum force measurement in muscle preparations. The difference in kinetic characteristics of the two isoforms could account for the difference in economy of force development and the basis for cardiac adaptation mechanism.", 
    "editor": [
      {
        "familyName": "Sugi", 
        "givenName": "Haruo", 
        "type": "Person"
      }, 
      {
        "familyName": "Pollack", 
        "givenName": "Gerald H.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-1-4684-6039-1_15", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-1-4684-6041-4", 
        "978-1-4684-6039-1"
      ], 
      "name": "Mechanisms of Work Production and Work Absorption in Muscle", 
      "type": "Book"
    }, 
    "keywords": [
      "cardiac myosin isoforms", 
      "myosin isoforms", 
      "ventricular muscle", 
      "young rats", 
      "muscle preparations", 
      "hypothyroid rats", 
      "V3 isoform", 
      "force development", 
      "isometric conditions", 
      "longer duration", 
      "rats", 
      "isoforms V1", 
      "vitro study", 
      "small latex beads", 
      "physiological significance", 
      "maximum force measurements", 
      "previous findings", 
      "latex beads", 
      "isoforms", 
      "same level", 
      "distinct kinetic properties", 
      "muscle", 
      "levels", 
      "differences", 
      "glass coverslips", 
      "duration", 
      "actomyosin interaction", 
      "motility", 
      "presence of ATP", 
      "V1", 
      "laser optical trap", 
      "findings", 
      "adaptation process", 
      "actin filaments", 
      "kinetic properties", 
      "significance", 
      "ATP", 
      "study", 
      "V3", 
      "myosin", 
      "coverslips", 
      "presence", 
      "mechanism", 
      "kinetic characteristics", 
      "development", 
      "end", 
      "hand", 
      "filaments", 
      "beads", 
      "preparation", 
      "measurements", 
      "adaptation mechanism", 
      "force measurements", 
      "amplitude", 
      "results", 
      "characteristics", 
      "basis", 
      "conditions", 
      "technique", 
      "redistribution", 
      "interaction", 
      "force", 
      "position", 
      "barbed ends", 
      "process", 
      "properties", 
      "microscope", 
      "agreement", 
      "distance", 
      "time-averaged force", 
      "traps", 
      "trap position", 
      "economy", 
      "optical trap", 
      "cardiac adaptation process", 
      "Cardiac myosin isoforms V1", 
      "myosin isoforms V1", 
      "unitary force measurement", 
      "cardiac adaptation mechanism"
    ], 
    "name": "Distinct Kinetic Properties of Cardiac Myosin Isoforms Revealed by In Vitro Studies", 
    "pagination": "125-130", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1035066345"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-1-4684-6039-1_15"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9889822"
        ]
      }
    ], 
    "publisher": {
      "name": "Springer Nature", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-1-4684-6039-1_15", 
      "https://app.dimensions.ai/details/publication/pub.1035066345"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2022-01-01T19:13", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/chapter/chapter_230.jsonl", 
    "type": "Chapter", 
    "url": "https://doi.org/10.1007/978-1-4684-6039-1_15"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4684-6039-1_15'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4684-6039-1_15'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4684-6039-1_15'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4684-6039-1_15'


 

This table displays all metadata directly associated to this object as RDF triples.

214 TRIPLES      23 PREDICATES      113 URIs      107 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-1-4684-6039-1_15 schema:about N18d37003841b4b5fae475e5b4f6f2c81
2 N39d44222a89f4146a74f6405eefedeb4
3 N54b5013af1484df8a155c0764f99ce5f
4 N6ed54d973a97427c8738adc2fc7d9864
5 N7cca506a6a6c41ef91dc828297967db1
6 Na51a66374f0b471fa4ef0e7af148483e
7 Nb349cce76d2047c4afa92547ad51fb7a
8 Nd61d761cd01142f6ad9ee047004f74a9
9 anzsrc-for:11
10 schema:author N1759bca430f1439f8a105a66fadef9e4
11 schema:datePublished 1998
12 schema:datePublishedReg 1998-01-01
13 schema:description To clarify the physiological significance of myosin isoform redistribution in cardiac adaptation process, we compared the kinetic property of the two cardiac myosin isoforms using in vitro motility assay techniques. Cardiac myosin isoforms V1 and V3 were obtained from ventricular muscle of young rats and hypothyroid rats respectively. On each of these myosin isoforms fixed on a glass coverslip, fluorescently labeled actin filaments were made to slide in the presence of ATP. To measure the force generated by actomyosin interaction, a small latex bead was attached to the barbed end of an actin filament and the bead was captured by the laser optical trap installed in a microscope. The force was determined from the distance between the bead and the trap positions under either auxotonic or isometric conditions. The time-averaged force generated by multiple cross-bridges did not differ significantly between the two isoforms. On the other hand, the unitary force measurement revealed the same level of amplitude but a longer duration for V3 isoform. The same level of time-averaged force is in agreement with not only our previous finding but the results of maximum force measurement in muscle preparations. The difference in kinetic characteristics of the two isoforms could account for the difference in economy of force development and the basis for cardiac adaptation mechanism.
14 schema:editor N67209822e36e461a95778f954c09b6ef
15 schema:genre chapter
16 schema:inLanguage en
17 schema:isAccessibleForFree false
18 schema:isPartOf N81ebed9f5aaa4a089ce315e52c5d9311
19 schema:keywords ATP
20 Cardiac myosin isoforms V1
21 V1
22 V3
23 V3 isoform
24 actin filaments
25 actomyosin interaction
26 adaptation mechanism
27 adaptation process
28 agreement
29 amplitude
30 barbed ends
31 basis
32 beads
33 cardiac adaptation mechanism
34 cardiac adaptation process
35 cardiac myosin isoforms
36 characteristics
37 conditions
38 coverslips
39 development
40 differences
41 distance
42 distinct kinetic properties
43 duration
44 economy
45 end
46 filaments
47 findings
48 force
49 force development
50 force measurements
51 glass coverslips
52 hand
53 hypothyroid rats
54 interaction
55 isoforms
56 isoforms V1
57 isometric conditions
58 kinetic characteristics
59 kinetic properties
60 laser optical trap
61 latex beads
62 levels
63 longer duration
64 maximum force measurements
65 measurements
66 mechanism
67 microscope
68 motility
69 muscle
70 muscle preparations
71 myosin
72 myosin isoforms
73 myosin isoforms V1
74 optical trap
75 physiological significance
76 position
77 preparation
78 presence
79 presence of ATP
80 previous findings
81 process
82 properties
83 rats
84 redistribution
85 results
86 same level
87 significance
88 small latex beads
89 study
90 technique
91 time-averaged force
92 trap position
93 traps
94 unitary force measurement
95 ventricular muscle
96 vitro study
97 young rats
98 schema:name Distinct Kinetic Properties of Cardiac Myosin Isoforms Revealed by In Vitro Studies
99 schema:pagination 125-130
100 schema:productId N1c1c54e8a76f4a0cbe5a88ea4cf00c3b
101 N463f8472c5ad4e71bfc00fdcd365bb06
102 Nd7a67ab394f848bea641bda831e86437
103 schema:publisher N1f2d2ba1ddde42bd8f60992f5ea33b0d
104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035066345
105 https://doi.org/10.1007/978-1-4684-6039-1_15
106 schema:sdDatePublished 2022-01-01T19:13
107 schema:sdLicense https://scigraph.springernature.com/explorer/license/
108 schema:sdPublisher N564f5c850b2248888b49ef9acb68cdab
109 schema:url https://doi.org/10.1007/978-1-4684-6039-1_15
110 sgo:license sg:explorer/license/
111 sgo:sdDataset chapters
112 rdf:type schema:Chapter
113 N1759bca430f1439f8a105a66fadef9e4 rdf:first sg:person.01277502614.69
114 rdf:rest N715abee9be0842049fee78290a3ba616
115 N18d37003841b4b5fae475e5b4f6f2c81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Myocardial Contraction
117 rdf:type schema:DefinedTerm
118 N1c1c54e8a76f4a0cbe5a88ea4cf00c3b schema:name pubmed_id
119 schema:value 9889822
120 rdf:type schema:PropertyValue
121 N1f2d2ba1ddde42bd8f60992f5ea33b0d schema:name Springer Nature
122 rdf:type schema:Organisation
123 N39d44222a89f4146a74f6405eefedeb4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Myosins
125 rdf:type schema:DefinedTerm
126 N463f8472c5ad4e71bfc00fdcd365bb06 schema:name doi
127 schema:value 10.1007/978-1-4684-6039-1_15
128 rdf:type schema:PropertyValue
129 N54b5013af1484df8a155c0764f99ce5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Kinetics
131 rdf:type schema:DefinedTerm
132 N564f5c850b2248888b49ef9acb68cdab schema:name Springer Nature - SN SciGraph project
133 rdf:type schema:Organization
134 N5e362f8c02de457487eb562452202c2a schema:familyName Sugi
135 schema:givenName Haruo
136 rdf:type schema:Person
137 N60ddd7fa32914f679d6f57bb7806798f rdf:first sg:person.01050463112.62
138 rdf:rest rdf:nil
139 N67209822e36e461a95778f954c09b6ef rdf:first N5e362f8c02de457487eb562452202c2a
140 rdf:rest Nac89d676ea844286a7c1a1aeece43d70
141 N6ed54d973a97427c8738adc2fc7d9864 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Rats, Wistar
143 rdf:type schema:DefinedTerm
144 N715abee9be0842049fee78290a3ba616 rdf:first sg:person.01211752724.24
145 rdf:rest Nec5361e6c2fe40d984af4b65b032206e
146 N7aefd3eeab434f6596b4fcf8ddd3b14f schema:familyName Pollack
147 schema:givenName Gerald H.
148 rdf:type schema:Person
149 N7cca506a6a6c41ef91dc828297967db1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Protein Isoforms
151 rdf:type schema:DefinedTerm
152 N81ebed9f5aaa4a089ce315e52c5d9311 schema:isbn 978-1-4684-6039-1
153 978-1-4684-6041-4
154 schema:name Mechanisms of Work Production and Work Absorption in Muscle
155 rdf:type schema:Book
156 Na51a66374f0b471fa4ef0e7af148483e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Animals
158 rdf:type schema:DefinedTerm
159 Na738e7e0c0ec4ecd9fc256696fbe680b rdf:first sg:person.0763036400.53
160 rdf:rest N60ddd7fa32914f679d6f57bb7806798f
161 Nac89d676ea844286a7c1a1aeece43d70 rdf:first N7aefd3eeab434f6596b4fcf8ddd3b14f
162 rdf:rest rdf:nil
163 Nb349cce76d2047c4afa92547ad51fb7a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Heart
165 rdf:type schema:DefinedTerm
166 Nd61d761cd01142f6ad9ee047004f74a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Rats
168 rdf:type schema:DefinedTerm
169 Nd7a67ab394f848bea641bda831e86437 schema:name dimensions_id
170 schema:value pub.1035066345
171 rdf:type schema:PropertyValue
172 Nec5361e6c2fe40d984af4b65b032206e rdf:first sg:person.01122202105.32
173 rdf:rest Nfd64fb2a352d4d91b60ba54bb798ef1a
174 Nfd64fb2a352d4d91b60ba54bb798ef1a rdf:first sg:person.01242732453.82
175 rdf:rest Na738e7e0c0ec4ecd9fc256696fbe680b
176 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
177 schema:name Medical and Health Sciences
178 rdf:type schema:DefinedTerm
179 sg:person.01050463112.62 schema:affiliation grid-institutes:grid.264706.1
180 schema:familyName Sugi
181 schema:givenName Haruo
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050463112.62
183 rdf:type schema:Person
184 sg:person.01122202105.32 schema:affiliation grid-institutes:grid.26999.3d
185 schema:familyName Fujita
186 schema:givenName Hideo
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122202105.32
188 rdf:type schema:Person
189 sg:person.01211752724.24 schema:affiliation grid-institutes:grid.26999.3d
190 schema:familyName Kobayakawa
191 schema:givenName Naoshi
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211752724.24
193 rdf:type schema:Person
194 sg:person.01242732453.82 schema:affiliation grid-institutes:grid.26999.3d
195 schema:familyName Momomura
196 schema:givenName Shin-ichi
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242732453.82
198 rdf:type schema:Person
199 sg:person.01277502614.69 schema:affiliation grid-institutes:grid.26999.3d
200 schema:familyName Sugiura
201 schema:givenName Seiryo
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277502614.69
203 rdf:type schema:Person
204 sg:person.0763036400.53 schema:affiliation grid-institutes:grid.264706.1
205 schema:familyName Chaen
206 schema:givenName Shigeru
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763036400.53
208 rdf:type schema:Person
209 grid-institutes:grid.264706.1 schema:alternateName Department of Physiology, Teikyo University School of Medicine, Itabashi-ku, Tokyo 173, Japan
210 schema:name Department of Physiology, Teikyo University School of Medicine, Itabashi-ku, Tokyo 173, Japan
211 rdf:type schema:Organization
212 grid-institutes:grid.26999.3d schema:alternateName The Second Department of Internal Medicine School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113, Japan
213 schema:name The Second Department of Internal Medicine School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113, Japan
214 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...