Structure-Function Analysis of the HIV Glycoprotein View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1991

AUTHORS

John W. Dubay , Hae-ja Shin , Jian-yun Dong , Susan Roberts , Eric Hunter

ABSTRACT

The envelope glycoprotein complex of replication competent retroviruses is comprised of two polypeptides, an external, glycosylated, hydrophilic polypeptide (SU) and a membrane-spanning protein (TM), that form a knob or knobbed spike on the surface of the virion. Both polypeptides are encoded in the env gene of the virus and are synthesized in the form of a polyprotein precursor that is proteolytically cleaved during its transport to the surface of the cell. While these proteins are not required for the assembly of enveloped virus particles, they do play a critical role in the virus replication cycle by recognizing and binding to specific receptors, via the SU domain, and by mediating the fusion of viral and cell membranes, via the TM domain: virus particles lacking envelope glycoproteins are thus non-infectious. More... »

PAGES

39-46

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4684-6000-1_5

DOI

http://dx.doi.org/10.1007/978-1-4684-6000-1_5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026647006

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1805575


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Products, env", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Precursors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Structure-Activity Relationship", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Microbiology, University of Alabama at Birmingham, UAB Station, 35294, Birmingham, AL, USA", 
          "id": "http://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Department of Microbiology, University of Alabama at Birmingham, UAB Station, 35294, Birmingham, AL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dubay", 
        "givenName": "John W.", 
        "id": "sg:person.01114727142.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114727142.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Microbiology, University of Alabama at Birmingham, UAB Station, 35294, Birmingham, AL, USA", 
          "id": "http://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Department of Microbiology, University of Alabama at Birmingham, UAB Station, 35294, Birmingham, AL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shin", 
        "givenName": "Hae-ja", 
        "id": "sg:person.01163042342.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163042342.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Microbiology, University of Alabama at Birmingham, UAB Station, 35294, Birmingham, AL, USA", 
          "id": "http://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Department of Microbiology, University of Alabama at Birmingham, UAB Station, 35294, Birmingham, AL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dong", 
        "givenName": "Jian-yun", 
        "id": "sg:person.012645750502.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012645750502.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Microbiology, University of Alabama at Birmingham, UAB Station, 35294, Birmingham, AL, USA", 
          "id": "http://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Department of Microbiology, University of Alabama at Birmingham, UAB Station, 35294, Birmingham, AL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roberts", 
        "givenName": "Susan", 
        "id": "sg:person.01012130464.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012130464.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Microbiology, University of Alabama at Birmingham, UAB Station, 35294, Birmingham, AL, USA", 
          "id": "http://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Department of Microbiology, University of Alabama at Birmingham, UAB Station, 35294, Birmingham, AL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hunter", 
        "givenName": "Eric", 
        "id": "sg:person.0731773046.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731773046.09"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1991", 
    "datePublishedReg": "1991-01-01", 
    "description": "The envelope glycoprotein complex of replication competent retroviruses is comprised of two polypeptides, an external, glycosylated, hydrophilic polypeptide (SU) and a membrane-spanning protein (TM), that form a knob or knobbed spike on the surface of the virion. Both polypeptides are encoded in the env gene of the virus and are synthesized in the form of a polyprotein precursor that is proteolytically cleaved during its transport to the surface of the cell. While these proteins are not required for the assembly of enveloped virus particles, they do play a critical role in the virus replication cycle by recognizing and binding to specific receptors, via the SU domain, and by mediating the fusion of viral and cell membranes, via the TM domain: virus particles lacking envelope glycoproteins are thus non-infectious.", 
    "editor": [
      {
        "familyName": "Atassi", 
        "givenName": "M. Zouhair", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-1-4684-6000-1_5", 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-1-4684-6002-5", 
        "978-1-4684-6000-1"
      ], 
      "name": "Immunobiology of Proteins and Peptides VI", 
      "type": "Book"
    }, 
    "keywords": [
      "virus particles", 
      "virus replication cycle", 
      "HIV glycoproteins", 
      "specific receptors", 
      "envelope glycoprotein", 
      "envelope glycoprotein complex", 
      "env gene", 
      "replication cycle", 
      "SU domain", 
      "critical role", 
      "glycoprotein complex", 
      "glycoprotein", 
      "replication competent retrovirus", 
      "cell membrane", 
      "receptors", 
      "polyprotein precursor", 
      "virus", 
      "protein", 
      "retroviruses", 
      "polypeptide", 
      "virions", 
      "cells", 
      "structure-function analysis", 
      "spikes", 
      "role", 
      "membrane-spanning proteins", 
      "genes", 
      "membrane", 
      "TM domain", 
      "fusion", 
      "analysis", 
      "cycle", 
      "knobs", 
      "precursors", 
      "form", 
      "domain", 
      "transport", 
      "complexes", 
      "hydrophilic polypeptide", 
      "surface", 
      "particles", 
      "assembly", 
      "competent retroviruses", 
      "knobbed spike"
    ], 
    "name": "Structure-Function Analysis of the HIV Glycoprotein", 
    "pagination": "39-46", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1026647006"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-1-4684-6000-1_5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "1805575"
        ]
      }
    ], 
    "publisher": {
      "name": "Springer Nature", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-1-4684-6000-1_5", 
      "https://app.dimensions.ai/details/publication/pub.1026647006"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2022-01-01T19:08", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/chapter/chapter_137.jsonl", 
    "type": "Chapter", 
    "url": "https://doi.org/10.1007/978-1-4684-6000-1_5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4684-6000-1_5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4684-6000-1_5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4684-6000-1_5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4684-6000-1_5'


 

This table displays all metadata directly associated to this object as RDF triples.

159 TRIPLES      22 PREDICATES      76 URIs      69 LITERALS      14 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-1-4684-6000-1_5 schema:about N121465ce0efb47969842eb76191706c6
2 N20e3fc84cfda47ed98d50a277c3790e2
3 N2fe0e39d15864e49aa4a8d2f7e658a77
4 N35c34c800e8b41f78473416c187c2855
5 N694e1826ed5e49a291cdb18e979cb3d0
6 Ne81448706e15499d9ea66f17eb943605
7 anzsrc-for:11
8 anzsrc-for:1108
9 schema:author N375f5f594f874dc2ad574a9f4533c4e6
10 schema:datePublished 1991
11 schema:datePublishedReg 1991-01-01
12 schema:description The envelope glycoprotein complex of replication competent retroviruses is comprised of two polypeptides, an external, glycosylated, hydrophilic polypeptide (SU) and a membrane-spanning protein (TM), that form a knob or knobbed spike on the surface of the virion. Both polypeptides are encoded in the env gene of the virus and are synthesized in the form of a polyprotein precursor that is proteolytically cleaved during its transport to the surface of the cell. While these proteins are not required for the assembly of enveloped virus particles, they do play a critical role in the virus replication cycle by recognizing and binding to specific receptors, via the SU domain, and by mediating the fusion of viral and cell membranes, via the TM domain: virus particles lacking envelope glycoproteins are thus non-infectious.
13 schema:editor N96f735fd2c364bb38dee383043047cfc
14 schema:genre chapter
15 schema:isAccessibleForFree false
16 schema:isPartOf N41838eb55de5418a93b1426b45cbf846
17 schema:keywords HIV glycoproteins
18 SU domain
19 TM domain
20 analysis
21 assembly
22 cell membrane
23 cells
24 competent retroviruses
25 complexes
26 critical role
27 cycle
28 domain
29 env gene
30 envelope glycoprotein
31 envelope glycoprotein complex
32 form
33 fusion
34 genes
35 glycoprotein
36 glycoprotein complex
37 hydrophilic polypeptide
38 knobbed spike
39 knobs
40 membrane
41 membrane-spanning proteins
42 particles
43 polypeptide
44 polyprotein precursor
45 precursors
46 protein
47 receptors
48 replication competent retrovirus
49 replication cycle
50 retroviruses
51 role
52 specific receptors
53 spikes
54 structure-function analysis
55 surface
56 transport
57 virions
58 virus
59 virus particles
60 virus replication cycle
61 schema:name Structure-Function Analysis of the HIV Glycoprotein
62 schema:pagination 39-46
63 schema:productId N363b256e58fa46c9804d688cd6864410
64 N67351ad5ac344eceb97ab56dd73b312e
65 Nc58fb82b6a3844989511d876e362ea51
66 schema:publisher Na0fcd04e83644296bb19cd7f8189bb38
67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026647006
68 https://doi.org/10.1007/978-1-4684-6000-1_5
69 schema:sdDatePublished 2022-01-01T19:08
70 schema:sdLicense https://scigraph.springernature.com/explorer/license/
71 schema:sdPublisher N2aa7ed063ad14d11b09663923ae6f81d
72 schema:url https://doi.org/10.1007/978-1-4684-6000-1_5
73 sgo:license sg:explorer/license/
74 sgo:sdDataset chapters
75 rdf:type schema:Chapter
76 N121465ce0efb47969842eb76191706c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Amino Acid Sequence
78 rdf:type schema:DefinedTerm
79 N20e3fc84cfda47ed98d50a277c3790e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Gene Products, env
81 rdf:type schema:DefinedTerm
82 N22c3e9f4c0b249be8e6b4ff5aeda3fe2 rdf:first sg:person.012645750502.11
83 rdf:rest N8c8837e939e9437b96c09c6a9d94cc4c
84 N2aa7ed063ad14d11b09663923ae6f81d schema:name Springer Nature - SN SciGraph project
85 rdf:type schema:Organization
86 N2acbec7b806d4e69afacffa7d763e23c schema:familyName Atassi
87 schema:givenName M. Zouhair
88 rdf:type schema:Person
89 N2d3aa27511654b4083e98d114c83c102 rdf:first sg:person.0731773046.09
90 rdf:rest rdf:nil
91 N2fe0e39d15864e49aa4a8d2f7e658a77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Molecular Sequence Data
93 rdf:type schema:DefinedTerm
94 N35c34c800e8b41f78473416c187c2855 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Protein Precursors
96 rdf:type schema:DefinedTerm
97 N363b256e58fa46c9804d688cd6864410 schema:name pubmed_id
98 schema:value 1805575
99 rdf:type schema:PropertyValue
100 N375f5f594f874dc2ad574a9f4533c4e6 rdf:first sg:person.01114727142.55
101 rdf:rest N5e8ced59eff94399a5b1fb273625c41f
102 N41838eb55de5418a93b1426b45cbf846 schema:isbn 978-1-4684-6000-1
103 978-1-4684-6002-5
104 schema:name Immunobiology of Proteins and Peptides VI
105 rdf:type schema:Book
106 N5e8ced59eff94399a5b1fb273625c41f rdf:first sg:person.01163042342.25
107 rdf:rest N22c3e9f4c0b249be8e6b4ff5aeda3fe2
108 N67351ad5ac344eceb97ab56dd73b312e schema:name dimensions_id
109 schema:value pub.1026647006
110 rdf:type schema:PropertyValue
111 N694e1826ed5e49a291cdb18e979cb3d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Mutation
113 rdf:type schema:DefinedTerm
114 N8c8837e939e9437b96c09c6a9d94cc4c rdf:first sg:person.01012130464.27
115 rdf:rest N2d3aa27511654b4083e98d114c83c102
116 N96f735fd2c364bb38dee383043047cfc rdf:first N2acbec7b806d4e69afacffa7d763e23c
117 rdf:rest rdf:nil
118 Na0fcd04e83644296bb19cd7f8189bb38 schema:name Springer Nature
119 rdf:type schema:Organisation
120 Nc58fb82b6a3844989511d876e362ea51 schema:name doi
121 schema:value 10.1007/978-1-4684-6000-1_5
122 rdf:type schema:PropertyValue
123 Ne81448706e15499d9ea66f17eb943605 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Structure-Activity Relationship
125 rdf:type schema:DefinedTerm
126 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
127 schema:name Medical and Health Sciences
128 rdf:type schema:DefinedTerm
129 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
130 schema:name Medical Microbiology
131 rdf:type schema:DefinedTerm
132 sg:person.01012130464.27 schema:affiliation grid-institutes:grid.265892.2
133 schema:familyName Roberts
134 schema:givenName Susan
135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012130464.27
136 rdf:type schema:Person
137 sg:person.01114727142.55 schema:affiliation grid-institutes:grid.265892.2
138 schema:familyName Dubay
139 schema:givenName John W.
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114727142.55
141 rdf:type schema:Person
142 sg:person.01163042342.25 schema:affiliation grid-institutes:grid.265892.2
143 schema:familyName Shin
144 schema:givenName Hae-ja
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163042342.25
146 rdf:type schema:Person
147 sg:person.012645750502.11 schema:affiliation grid-institutes:grid.265892.2
148 schema:familyName Dong
149 schema:givenName Jian-yun
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012645750502.11
151 rdf:type schema:Person
152 sg:person.0731773046.09 schema:affiliation grid-institutes:grid.265892.2
153 schema:familyName Hunter
154 schema:givenName Eric
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731773046.09
156 rdf:type schema:Person
157 grid-institutes:grid.265892.2 schema:alternateName Department of Microbiology, University of Alabama at Birmingham, UAB Station, 35294, Birmingham, AL, USA
158 schema:name Department of Microbiology, University of Alabama at Birmingham, UAB Station, 35294, Birmingham, AL, USA
159 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...