Structure-Function Analysis of the HIV Glycoprotein View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1991

AUTHORS

John W. Dubay , Hae-ja Shin , Jian-yun Dong , Susan Roberts , Eric Hunter

ABSTRACT

The envelope glycoprotein complex of replication competent retroviruses is comprised of two polypeptides, an external, glycosylated, hydrophilic polypeptide (SU) and a membrane-spanning protein (TM), that form a knob or knobbed spike on the surface of the virion. Both polypeptides are encoded in the env gene of the virus and are synthesized in the form of a polyprotein precursor that is proteolytically cleaved during its transport to the surface of the cell. While these proteins are not required for the assembly of enveloped virus particles, they do play a critical role in the virus replication cycle by recognizing and binding to specific receptors, via the SU domain, and by mediating the fusion of viral and cell membranes, via the TM domain: virus particles lacking envelope glycoproteins are thus non-infectious. More... »

PAGES

39-46

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4684-6000-1_5

DOI

http://dx.doi.org/10.1007/978-1-4684-6000-1_5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026647006

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1805575


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