HIV-1 Neutralizing Antibody and Approaches to the Envelope Diversity Problem View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1991

AUTHORS

Thomas J. Matthews , Alphonse J. Langlois , Stephano Butto , Dani Bolognesi , Kashi Javaherian

ABSTRACT

Since the discovery of human immunodeficiency virus (HIV) as the causative agent of AIDS in 1983–84, there has been considerable effort to design an efficacious vaccine. Principally for safety reasons, defined subunit polypeptides and proteins devoid of genomic material have been considered as alternatives to attenuated and/or killed virus. Much of the effort to develope such a component vaccine against HIV has been directed at the envelope gene products. These have included recombinant gp l60 (1,2,3), recombinant gp 120 (4,5,6), native viral gp 120 (7,8,9), bacterially expressed envelope fragments (10), and a large number of synthetic peptides (11–19). In these early studies each of the various reagents were tested for their ability to raise neutralizing antibodies in experimental animals. When successful, resultant sera were usually found to be active only against homologous virus, i.e. were isolate restricted. The results suggested that variable sites on the envelope represented the major target of neutralizing antibody raised by the various experimental immunogens. More... »

PAGES

23-6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4684-6000-1_3

DOI

http://dx.doi.org/10.1007/978-1-4684-6000-1_3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013446913

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1725234


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