Development of Non-Toxigenic Vaccine Strains of Bordetella pertussis by Gene Replacement View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1991

AUTHORS

S. Cockle , G. Zealey , S. Loosmore , R. Yacoob , R. Fahim , Y.-P. Yang , G. Jackson , H. Boux , L. Boux , M. Klein

ABSTRACT

During the next decade, it is likely that current whole-cell whooping cough vaccines prepared from inactivated Bordetella pertussis will be replaced by component vaccines of defined purity and composition that offer higher efficacy and reduced reactogenicity. The principal B. pertussis antigens under consideration for such vaccines are pertussis toxin (PT), filamentous hemagglutinin (FHA), pertactin (69 kDa protein) and fimbrial agglutinogens. Although PT is a potent immunogen, it is also a major virulence factor of B. pertussis. However, the chemical treatments now used to inactivate PT can reduce its immunogenicity, and depending on the method used, may be susceptible to reversion. An ideal approach to PT detoxification is the genetic replacement or removal of a few critical functional amino acid residues so that three-dimensional structure and immunogenicity are only minimally impaired. More... »

PAGES

221-5

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4684-6000-1_24

DOI

http://dx.doi.org/10.1007/978-1-4684-6000-1_24

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046524301

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1805567


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