Role and Mechanism of Hexokinase Decay During Reticulocyte Maturation and Cell Aging View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1991

AUTHORS

Mauro Magnani , Luigia Rossi , Marzia Bianchi , Giordano Serafini , Vilberto Stocchi

ABSTRACT

Human red blood cells (RBC) as well as the erythrocytes of many mammals are removed from circulation at the end of their life by an impressively efficient biological mechanism that is not fully understood. It is commonly accepted that senescent erythrocytes are selectively recognized and removed from the circulation by spleen and liver macrophages (1), however, various mechanisms have been proposed to account for this selectivity (for a review see Blood Cells vol. 14, 1988). Among these, the immunologic mechanism of cellular removal is widely accepted although the precise identity of the senescent cell antigen(s) remains to be established and primary mechanism of red blood cell aging leading to immunoglobins and complement binding have yet to be elucidated. More... »

PAGES

29-35

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4684-5985-2_3

DOI

http://dx.doi.org/10.1007/978-1-4684-5985-2_3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008002503

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1805592


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