Kynurenine 3-Monooxygenase Activity of Rat Brain Mitochondria Determined by High Performance Liquid Chromatography with Electrochemical Detection View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1991

AUTHORS

T. Uemura , K. Hirai

ABSTRACT

Among the enzymes of the kynurenine pathway in brain, the presence of the following five enzymes has been reported: IDO (Gál, 1974), kynurenine 3-monooxygenase (Battie and Verity, 1981), kynureninase (Kawai et al., 1988), 3-OHAADO (Foster et al., 1986) and QPRT (Foster et al., 1985)*. The reported specific activity of rat brain mitochondrial kynurenine 3-monooxygenase is rather higher than that of liver. We have now reexamined this enzyme activity in rat brain mitochondria by using a new, highly sensitive assay method (HPLC-ECD). The enzyme activity of rat brain mitochondria is lower than that of liver mitochondria. More... »

PAGES

531-534

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4684-5952-4_61

DOI

http://dx.doi.org/10.1007/978-1-4684-5952-4_61

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044899472

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1772088


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