Single sc Administration of Insulin-Like Growth Factor I (IGF-I) in Normal Men View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1991

AUTHORS

Naomi Hizuka , Kazue Takano , Kumiko Asakawa , Izumi Fukuda , Izumi Sukegawa , Kazuo Shizume , Hiroshi Demura

ABSTRACT

Insulin-like growth factor I (IGF-I) has been synthesized by recombinant DNA technology (1). With the availability of large quantities of the biosynthetic peptide, the biological effects have been studied in animals in vivo. We have previously reported that IGF-I has growth promoting, anabolic, and insulin-like effects in hypophysectomized and normal rats, and IGF-I inhibits catabolism in fasted rats in vivo (2–5). Recently, the biological effects of IGF-I have been studied in normal men and patients with Laron-type dwarfism (6–9). We have also studied effects of IGF-I single sc administration in normal men (10). In this paper, the results of the single sc administration of IGF-I combined with our previous data (10) are reported. More... »

PAGES

105-112

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4684-5949-4_10

DOI

http://dx.doi.org/10.1007/978-1-4684-5949-4_10

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021987519

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1767729


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