γδ T Cells in Murine Epithelia: Origin, Repertoire, and Function View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1991

AUTHORS

James P. Allison , David M. Asarnow , Mark Bonyhadi , Amy Carbone , Wendy L. Havran , Diphankar Nandi , Janelle Noble

ABSTRACT

The earliest TCR+ cells to appear during fetal development express products of the gamma and delta loci, and emerge as successive waves of cells bearing different V gamma gene products. These appear to emigrate and seed different epithelia. The TCR repertoire of the first two of these waves, V gamma 3 and V gamma 4, respectively, is extremely restricted. Whether the repertoire of these cells is restricted by selective processes or is shaped by developmental restrictions on rearrangements remains to be determined. These cells may function in surveillance for signals of trauma by recognizing self products induced by cellular stress. More... »

PAGES

63-9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4684-5943-2_8

DOI

http://dx.doi.org/10.1007/978-1-4684-5943-2_8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024211553

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1835264


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