Thymic Mechanisms for Inducing Tolerance to Mls View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1991

AUTHORS

Fred Ramsdell , Tracy Lantz , Frances Hausman , B. J. Fowlkes

ABSTRACT

As T cells develop in the thymus, they are subjected to a number of selective events which determine the antigen recognition repertoire of mature T cells. Also, as a result of selection, T cells emerge that are able to distinguish self from non-self. A number of mechanisms have been proposed for establishing self tolerance.1 In this report, it is demonstrated that T cells developing in the thymus become tolerant of the minor lymphocyte stimulatory antigens, Mis,2-4 by at least two distinct mechanisms. Through the use of V/9-specific antibodies that identify receptors with Mls specificity,5-7 it is possible to show that tolerance to this self antigen can be acquired by clonal deletion or functional inacti-vation (clonal anergy). Whether tolerance to Mls is achieved and the type of tolerance induced appears to be critically dependent upon a number of factors, most notably the MHC haplotype, the tissue involved in antigen presentation, and the type of Mis antigen (Mls-1 or Mls-2). Here, chimeric animals are used in order to manipulate the site of tissue expression of MHC and Mls antigens. The results obtained reveal that clonal deletion is dependent on the type of MHC expressed by the bone marrow-derived elements and not on the tissue source of the Mls antigen. Furthermore, in the absence of clonal deletion, tolerance to Mls can be achieved by clonal anergy. This latter form of tolerance induction appears to be the result of interactions with radiation-resistant host elements, most likely the thymic epithelium. More... »

PAGES

139-47

References to SciGraph publications

  • 1989-02. Thymic cortical epithelial cells can present self-antigens in vivo in NATURE
  • 1988-06. Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes in NATURE
  • 1988-10. Self-tolerance alters T-cell receptor expression in an antigen-specific MHC restricted immune response in NATURE
  • 1988-09. Intrathymic deletion of self-reactive cells prevented by neonatal anti-CD4 antibody treatment in NATURE
  • 1988-03. Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex in NATURE
  • 1980-10. T lymphocytes responding to Mls-locus antigens are Lyt-1+, 2− andI-A restricted in IMMUNOGENETICS
  • 1988-03. T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens in NATURE
  • 1988-10. Preferential expression of the T-cell receptor Vβ3 gene by Mlsc reactive T cells in NATURE
  • 1988-10. The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens in NATURE
  • 1989-08. Thymic cortical epithelial cells lack full capacity for antigen presentation in NATURE
  • 1982-07. Cytotoxic monoclonal antibody specific for the Lyt-1.2 antigen in IMMUNOGENETICS
  • 1989-08. Phenotypic differences between αβ versus β T-cell receptor transgenic mice undergoing negative selection in NATURE
  • 1988-11. Positive and negative selection of an antigen receptor on T cells in transgenic mice in NATURE
  • 1989-05. High-affinity binding of staphylococcal enterotoxins A and B to HLA-DR in NATURE
  • 1987-11. Expression and function of the CD3-antigen receptor on murine CD4+8+ thymocytes in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-4684-5943-2_16

    DOI

    http://dx.doi.org/10.1007/978-1-4684-5943-2_16

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1024529125

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1835260


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