Alteration of [3H] Ins (1,4,5) P3 and [3H] PDBu Binding Sites in Brains of Patients with Parkinson’s Disease and Multiple ... View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1990

AUTHORS

Takeshi Hashimoto , Yasuo Kajimoto , Yutaka Shirai , Naoya Murakami , Naoki Nishino , Seiji Noguchi , Osamu Komure , Sadako Kuno , Norio Sakai , Noboru Kitamura , Chikako Tanaka

ABSTRACT

The roles of membrane inositol phospholipid turnover in intracellular signal transduction have been vigorously researched. Stimulation of several receptors by neurotransmitters, hormones, and growth factors leads to accelerated turnover of polyphosphoinositides. Hydrolysis of phosphatidylinositol 4,5-bisphosphate by activated phospholipase C generates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and 1,2-diacylglycerol, both of which act as second messengers. The former increases intracellular Ca2+ and the latter activates protein kinase C (PKC) (Nishizuka, 1986). More... »

PAGES

605-608

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4684-5844-2_122

DOI

http://dx.doi.org/10.1007/978-1-4684-5844-2_122

DIMENSIONS

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