Molecular Markers of Reactive Plasticity View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1990

AUTHORS

James W. Geddes , Michael C. Wilson , Freda D. Miller , Carl W. Cotman

ABSTRACT

Reactive plasticity, including axonal and dendritic sprouting and reactive synaptogenesis, has been proposed to contribute to the pathogenesis of several neurological disorders. We have obtained evidence suggestive of plasticity in Alzheimer’s disease and temporal lobe epilepsy. In each of these disorders, an altered distribution of excitatory amino acid receptors, particularly of the kainic acid subtype, was observed in the hippocampal formation (Geddes et al., 1985; Cahan et al., 1987; Geddes et al., submitted). Altered distribution of kainic acid binding sites has also been observed in other forms of childhood epilepsy (Represa et al., 1989). Additional markers of plasticity in human neurological disorders have included intensification of acetylcholinesterase staining in Alzheimer’s disease (Geddes et al., 1985), and supragranular Timm’s staining in temporal lobe epilepsy (Babb et al., 1988). Although these results are suggestive of sprouting, this interpretation is open to question. The increase in receptor density could simply be the result of receptor upregulation. The intensification of Timm’s staining could result from increased zinc in existing terminals, and intensification of acetylcholinesterase staining is also relatively nonspecific. In addition to their lack of specificity, many of the morphological methods used to demonstrate sprouting in the rodent brain are unsuitable for use in postmortem human tissue. For example, Timm staining requires perfusion with a sulfide solution for optimal results. More... »

PAGES

425-432

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4684-5769-8_47

DOI

http://dx.doi.org/10.1007/978-1-4684-5769-8_47

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029093897

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2075860


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hippocampus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nerve Tissue Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuronal Plasticity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Synapses", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Synaptosomal-Associated Protein 25", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tubulin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Div. Neurosurgery, Univ. Calif., 92717, Irvine, CA, USA", 
          "id": "http://www.grid.ac/institutes/grid.266093.8", 
          "name": [
            "Div. Neurosurgery, Univ. Calif., 92717, Irvine, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Geddes", 
        "givenName": "James W.", 
        "id": "sg:person.0725326750.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725326750.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dept. Neuropharmacology, Scripps Clinic & Res. Foundation, 92037, La Jolla, CA, USA", 
          "id": "http://www.grid.ac/institutes/grid.214007.0", 
          "name": [
            "Dept. Neuropharmacology, Scripps Clinic & Res. Foundation, 92037, La Jolla, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wilson", 
        "givenName": "Michael C.", 
        "id": "sg:person.01110715057.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110715057.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dept. Anatomy & Cell Biology, Univ. Alberta Edmonton, Canada", 
          "id": "http://www.grid.ac/institutes/grid.17089.37", 
          "name": [
            "Dept. Anatomy & Cell Biology, Univ. Alberta Edmonton, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miller", 
        "givenName": "Freda D.", 
        "id": "sg:person.011535750057.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011535750057.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dept. Psychobiology, Univ. Calif., 92717, Irvine, CA, USA", 
          "id": "http://www.grid.ac/institutes/grid.266093.8", 
          "name": [
            "Dept. Psychobiology, Univ. Calif., 92717, Irvine, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cotman", 
        "givenName": "Carl W.", 
        "id": "sg:person.0716606642.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716606642.72"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1990", 
    "datePublishedReg": "1990-01-01", 
    "description": "Reactive plasticity, including axonal and dendritic sprouting and reactive synaptogenesis, has been proposed to contribute to the pathogenesis of several neurological disorders. We have obtained evidence suggestive of plasticity in Alzheimer\u2019s disease and temporal lobe epilepsy. In each of these disorders, an altered distribution of excitatory amino acid receptors, particularly of the kainic acid subtype, was observed in the hippocampal formation (Geddes et al., 1985; Cahan et al., 1987; Geddes et al., submitted). Altered distribution of kainic acid binding sites has also been observed in other forms of childhood epilepsy (Represa et al., 1989). Additional markers of plasticity in human neurological disorders have included intensification of acetylcholinesterase staining in Alzheimer\u2019s disease (Geddes et al., 1985), and supragranular Timm\u2019s staining in temporal lobe epilepsy (Babb et al., 1988). Although these results are suggestive of sprouting, this interpretation is open to question. The increase in receptor density could simply be the result of receptor upregulation. The intensification of Timm\u2019s staining could result from increased zinc in existing terminals, and intensification of acetylcholinesterase staining is also relatively nonspecific. In addition to their lack of specificity, many of the morphological methods used to demonstrate sprouting in the rodent brain are unsuitable for use in postmortem human tissue. For example, Timm staining requires perfusion with a sulfide solution for optimal results.", 
    "editor": [
      {
        "familyName": "Ben-Ari", 
        "givenName": "Yehezkel", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-1-4684-5769-8_47", 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-1-4684-5771-1", 
        "978-1-4684-5769-8"
      ], 
      "name": "Excitatory Amino Acids and Neuronal Plasticity", 
      "type": "Book"
    }, 
    "keywords": [
      "temporal lobe epilepsy", 
      "Timm staining", 
      "lobe epilepsy", 
      "reactive plasticity", 
      "acetylcholinesterase staining", 
      "neurological disorders", 
      "Alzheimer's disease", 
      "excitatory amino acid receptors", 
      "amino acid receptors", 
      "postmortem human tissue", 
      "altered distribution", 
      "dendritic sprouting", 
      "human neurological disorders", 
      "receptor upregulation", 
      "kainic acid", 
      "childhood epilepsy", 
      "reactive synaptogenesis", 
      "receptor density", 
      "hippocampal formation", 
      "rodent brain", 
      "acid subtype", 
      "acid receptors", 
      "lack of specificity", 
      "epilepsy", 
      "disease", 
      "staining", 
      "disorders", 
      "additional markers", 
      "human tissues", 
      "sprouting", 
      "markers", 
      "plasticity", 
      "pathogenesis", 
      "perfusion", 
      "subtypes", 
      "synaptogenesis", 
      "brain", 
      "receptors", 
      "upregulation", 
      "molecular markers", 
      "tissue", 
      "specificity", 
      "morphological methods", 
      "evidence", 
      "results", 
      "increase", 
      "lack", 
      "optimal results", 
      "terminals", 
      "acid", 
      "use", 
      "addition", 
      "sites", 
      "zinc", 
      "questions", 
      "form", 
      "distribution", 
      "intensification", 
      "method", 
      "formation", 
      "interpretation", 
      "density", 
      "example", 
      "solution", 
      "sulfide solution"
    ], 
    "name": "Molecular Markers of Reactive Plasticity", 
    "pagination": "425-432", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1029093897"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-1-4684-5769-8_47"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "2075860"
        ]
      }
    ], 
    "publisher": {
      "name": "Springer Nature", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-1-4684-5769-8_47", 
      "https://app.dimensions.ai/details/publication/pub.1029093897"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2022-11-24T21:13", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/chapter/chapter_206.jsonl", 
    "type": "Chapter", 
    "url": "https://doi.org/10.1007/978-1-4684-5769-8_47"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4684-5769-8_47'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4684-5769-8_47'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4684-5769-8_47'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4684-5769-8_47'


 

This table displays all metadata directly associated to this object as RDF triples.

201 TRIPLES      22 PREDICATES      102 URIs      95 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-1-4684-5769-8_47 schema:about N315aa8668e484ea391942616d678040c
2 N32ef0b42ba164f12bf0083ab380e1371
3 N3345270bfba7455186eba45c09a23885
4 N42c26451b7e44114b0fa53aab70afe39
5 N5cdbb37476b54631872385c907ecd1e1
6 N5d084c93ad1d4721b18a51c9101af571
7 N6eb174c1f1c1402187a2b0a524451e05
8 N731eb6ee933a41d18a541926134727ec
9 N9b771f29a34844d4a9a9e0ffa7bfe9bb
10 Nb98f830a1414436c86773cd93c8d3569
11 Nfe0c511aa7034d0eaef487915b026b20
12 anzsrc-for:11
13 anzsrc-for:1109
14 schema:author N2ea77eb64c944f269eefc5134f128f94
15 schema:datePublished 1990
16 schema:datePublishedReg 1990-01-01
17 schema:description Reactive plasticity, including axonal and dendritic sprouting and reactive synaptogenesis, has been proposed to contribute to the pathogenesis of several neurological disorders. We have obtained evidence suggestive of plasticity in Alzheimer’s disease and temporal lobe epilepsy. In each of these disorders, an altered distribution of excitatory amino acid receptors, particularly of the kainic acid subtype, was observed in the hippocampal formation (Geddes et al., 1985; Cahan et al., 1987; Geddes et al., submitted). Altered distribution of kainic acid binding sites has also been observed in other forms of childhood epilepsy (Represa et al., 1989). Additional markers of plasticity in human neurological disorders have included intensification of acetylcholinesterase staining in Alzheimer’s disease (Geddes et al., 1985), and supragranular Timm’s staining in temporal lobe epilepsy (Babb et al., 1988). Although these results are suggestive of sprouting, this interpretation is open to question. The increase in receptor density could simply be the result of receptor upregulation. The intensification of Timm’s staining could result from increased zinc in existing terminals, and intensification of acetylcholinesterase staining is also relatively nonspecific. In addition to their lack of specificity, many of the morphological methods used to demonstrate sprouting in the rodent brain are unsuitable for use in postmortem human tissue. For example, Timm staining requires perfusion with a sulfide solution for optimal results.
18 schema:editor Nb0b883ef37fb443782046405d6c34090
19 schema:genre chapter
20 schema:isAccessibleForFree false
21 schema:isPartOf Nee7c778214a248a9b5ea68419a124859
22 schema:keywords Alzheimer's disease
23 Timm staining
24 acetylcholinesterase staining
25 acid
26 acid receptors
27 acid subtype
28 addition
29 additional markers
30 altered distribution
31 amino acid receptors
32 brain
33 childhood epilepsy
34 dendritic sprouting
35 density
36 disease
37 disorders
38 distribution
39 epilepsy
40 evidence
41 example
42 excitatory amino acid receptors
43 form
44 formation
45 hippocampal formation
46 human neurological disorders
47 human tissues
48 increase
49 intensification
50 interpretation
51 kainic acid
52 lack
53 lack of specificity
54 lobe epilepsy
55 markers
56 method
57 molecular markers
58 morphological methods
59 neurological disorders
60 optimal results
61 pathogenesis
62 perfusion
63 plasticity
64 postmortem human tissue
65 questions
66 reactive plasticity
67 reactive synaptogenesis
68 receptor density
69 receptor upregulation
70 receptors
71 results
72 rodent brain
73 sites
74 solution
75 specificity
76 sprouting
77 staining
78 subtypes
79 sulfide solution
80 synaptogenesis
81 temporal lobe epilepsy
82 terminals
83 tissue
84 upregulation
85 use
86 zinc
87 schema:name Molecular Markers of Reactive Plasticity
88 schema:pagination 425-432
89 schema:productId N52052d161bfe460cbbeb741e21f25811
90 Nb2b8081d9ebf4236a652f3122e863401
91 Nd3d605e519004519a0fc8d099492b88a
92 schema:publisher N3a6d7f5387964250ba851516cd380da2
93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029093897
94 https://doi.org/10.1007/978-1-4684-5769-8_47
95 schema:sdDatePublished 2022-11-24T21:13
96 schema:sdLicense https://scigraph.springernature.com/explorer/license/
97 schema:sdPublisher Na72061f875c241ff94e0e5f0c8b6d7dc
98 schema:url https://doi.org/10.1007/978-1-4684-5769-8_47
99 sgo:license sg:explorer/license/
100 sgo:sdDataset chapters
101 rdf:type schema:Chapter
102 N2233101f12e348e88e7eabc5ea4c36ab rdf:first sg:person.01110715057.57
103 rdf:rest N91ec25ab605445b1867c0f24a981510f
104 N2ea77eb64c944f269eefc5134f128f94 rdf:first sg:person.0725326750.48
105 rdf:rest N2233101f12e348e88e7eabc5ea4c36ab
106 N315aa8668e484ea391942616d678040c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Tubulin
108 rdf:type schema:DefinedTerm
109 N32ef0b42ba164f12bf0083ab380e1371 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Hippocampus
111 rdf:type schema:DefinedTerm
112 N3345270bfba7455186eba45c09a23885 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Biomarkers
114 rdf:type schema:DefinedTerm
115 N3a6d7f5387964250ba851516cd380da2 schema:name Springer Nature
116 rdf:type schema:Organisation
117 N42c26451b7e44114b0fa53aab70afe39 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Membrane Proteins
119 rdf:type schema:DefinedTerm
120 N52052d161bfe460cbbeb741e21f25811 schema:name dimensions_id
121 schema:value pub.1029093897
122 rdf:type schema:PropertyValue
123 N5cdbb37476b54631872385c907ecd1e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Animals
125 rdf:type schema:DefinedTerm
126 N5d084c93ad1d4721b18a51c9101af571 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name RNA, Messenger
128 rdf:type schema:DefinedTerm
129 N6eb174c1f1c1402187a2b0a524451e05 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Synaptosomal-Associated Protein 25
131 rdf:type schema:DefinedTerm
132 N731eb6ee933a41d18a541926134727ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Synapses
134 rdf:type schema:DefinedTerm
135 N91ec25ab605445b1867c0f24a981510f rdf:first sg:person.011535750057.00
136 rdf:rest Nb573908c178a4751bc90b6d68d7048d7
137 N9b771f29a34844d4a9a9e0ffa7bfe9bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Nerve Tissue Proteins
139 rdf:type schema:DefinedTerm
140 Na72061f875c241ff94e0e5f0c8b6d7dc schema:name Springer Nature - SN SciGraph project
141 rdf:type schema:Organization
142 Nb0b883ef37fb443782046405d6c34090 rdf:first Ne989ef6bf322407e8ef81548ccd74078
143 rdf:rest rdf:nil
144 Nb2b8081d9ebf4236a652f3122e863401 schema:name doi
145 schema:value 10.1007/978-1-4684-5769-8_47
146 rdf:type schema:PropertyValue
147 Nb573908c178a4751bc90b6d68d7048d7 rdf:first sg:person.0716606642.72
148 rdf:rest rdf:nil
149 Nb98f830a1414436c86773cd93c8d3569 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Humans
151 rdf:type schema:DefinedTerm
152 Nd3d605e519004519a0fc8d099492b88a schema:name pubmed_id
153 schema:value 2075860
154 rdf:type schema:PropertyValue
155 Ne989ef6bf322407e8ef81548ccd74078 schema:familyName Ben-Ari
156 schema:givenName Yehezkel
157 rdf:type schema:Person
158 Nee7c778214a248a9b5ea68419a124859 schema:isbn 978-1-4684-5769-8
159 978-1-4684-5771-1
160 schema:name Excitatory Amino Acids and Neuronal Plasticity
161 rdf:type schema:Book
162 Nfe0c511aa7034d0eaef487915b026b20 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Neuronal Plasticity
164 rdf:type schema:DefinedTerm
165 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
166 schema:name Medical and Health Sciences
167 rdf:type schema:DefinedTerm
168 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
169 schema:name Neurosciences
170 rdf:type schema:DefinedTerm
171 sg:person.01110715057.57 schema:affiliation grid-institutes:grid.214007.0
172 schema:familyName Wilson
173 schema:givenName Michael C.
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110715057.57
175 rdf:type schema:Person
176 sg:person.011535750057.00 schema:affiliation grid-institutes:grid.17089.37
177 schema:familyName Miller
178 schema:givenName Freda D.
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011535750057.00
180 rdf:type schema:Person
181 sg:person.0716606642.72 schema:affiliation grid-institutes:grid.266093.8
182 schema:familyName Cotman
183 schema:givenName Carl W.
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716606642.72
185 rdf:type schema:Person
186 sg:person.0725326750.48 schema:affiliation grid-institutes:grid.266093.8
187 schema:familyName Geddes
188 schema:givenName James W.
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725326750.48
190 rdf:type schema:Person
191 grid-institutes:grid.17089.37 schema:alternateName Dept. Anatomy & Cell Biology, Univ. Alberta Edmonton, Canada
192 schema:name Dept. Anatomy & Cell Biology, Univ. Alberta Edmonton, Canada
193 rdf:type schema:Organization
194 grid-institutes:grid.214007.0 schema:alternateName Dept. Neuropharmacology, Scripps Clinic & Res. Foundation, 92037, La Jolla, CA, USA
195 schema:name Dept. Neuropharmacology, Scripps Clinic & Res. Foundation, 92037, La Jolla, CA, USA
196 rdf:type schema:Organization
197 grid-institutes:grid.266093.8 schema:alternateName Dept. Psychobiology, Univ. Calif., 92717, Irvine, CA, USA
198 Div. Neurosurgery, Univ. Calif., 92717, Irvine, CA, USA
199 schema:name Dept. Psychobiology, Univ. Calif., 92717, Irvine, CA, USA
200 Div. Neurosurgery, Univ. Calif., 92717, Irvine, CA, USA
201 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...