Cytoplasmic Islet Cell Autoantibodies: Prevalence and Pathognomic Significance View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1988

AUTHORS

Helga Gleichmann , Gian Franco Bottazzo , Friedrich Arnold Gries

ABSTRACT

For many decades insulin-dependent diabetes mellitus (IDDM = Type I diabetes) has been regarded as a metabolic disorder with a typical acute clinical onset. In the past 15 years, however, there have been substantial changes in previously established concepts of the etiopathogenesis of Type I diabetes (1,2). Based on immunologic, genetic and epidemiologic studies it is apparent that the majority of patients with Type I diabetes have a long, clinically silent prediabetic period. This latency period, which can antedate clinically overt manifestation of insulin-deficiency for up to several years, is featured by the presence of various autoimmune phenomena (2,3). Currently chronic autoimmune reactions are widely believed to play a key role in the progressive destruction of the insulin-producing beta-cells of the Langerhans islets, although a direct autoimmune attack has still to be proved. More... »

PAGES

71-7

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4684-5616-5_9

DOI

http://dx.doi.org/10.1007/978-1-4684-5616-5_9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005486576

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3074670


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