Synthesis of Antitumor Polysaccharides View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1988

AUTHORS

Kei Matsuzaki , Iwao Yamamoto , Koji Enomoto , Yutaro Kaneko , Tohru Mimura , Tsuyoshi Shiio

ABSTRACT

Previously, we have synthesized several antitumor polysaccharides having D-glucopyranose, D-mannopyranose, D-ara-binofuranose, or its oligomer, as side chains of (1→3)-β-glucan, or (1→4)-β-glucan by the orthoester method as models of natural antitumor polysaccharides, such as lentinan, etc. Some of these have indicated high antitumor activity against Sarcoma 180 implanted into mice, to the same extent as the natural polysaccharides. In this report, water soluble, branched polysaccharides having L-arabinofuranose or its oligomer, L-arabinopyranose, or D-galactopyranose as side chains were synthesized, and their structures and antitumor activities were determined, in order to investigate the effect of the kind of side chains on the antitumor activity. These synthetic polysaccharides showed high antitumor activity. More... »

PAGES

165-174

Book

TITLE

Applied Bioactive Polymeric Materials

ISBN

978-1-4684-5612-7
978-1-4684-5610-3

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4684-5610-3_13

DOI

http://dx.doi.org/10.1007/978-1-4684-5610-3_13

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005001737


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