Paraquat-Resistant HeLa Cells View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1988

AUTHORS

J. Krall , A. C. Bagley , G. M. Mullenbach , R. A. Hallewell , R. E. Lynch

ABSTRACT

The cytotoxic action of chemicals which transfer electrons from biological reductants to molecular oxygen is believed to result from the formation of •O2-, H2O2, and •OH. Paraquat is one such agent which appears to act in Escherichia coli primarily by generating •O2-, but necessarily H2O2 as well. To have its cytotoxic action by promoting the intracellular formation of •O2- paraquat must first be taken up by the cell, it must then be reduced by one electron to form the paraquat radical, and finally it must auto-oxidize to yield •O2-. If this scheme is correct for mammalian cells as it appears to be for prokaryotes,1 cells which adapt to growth in the presence of paraquat should modify one or more of these steps, probably by mutation or other genetic adaptation, such as amplification of genes for the superoxide dismutases or for catalase, as a means of increasing the cellular content of enzymes which scavenge •O2- or H2O2, respectively. More... »

PAGES

811-814

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4684-5568-7_130

DOI

http://dx.doi.org/10.1007/978-1-4684-5568-7_130

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051412447


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