Therapeutic Efficacy of Oxazaphosphorines by Immunomodulation View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1986

AUTHORS

R. Voegeli , J. Pohl , T. Reissmann , J. Stekar , P. Hilgard

ABSTRACT

Cyclophosphamide and a few related compounds of the class of oxazaphosphorines are widely used in the chemotherapy of malignant diseases. Their antitumour efficacy is based on their cytotoxic activity against quickly proliferating cells. Beside this, these agents are strong immunosuppressants and a particularly high sensitivity of antibody-producing, proliferating B cells was postulated (1). In contrast, it could be shown that cyclophosphamide in non-toxic doses enhanced delayed-type hypersensitivity reactions, which indicated a selective effect of cyclophosphamide on T cells (2,3). More... »

PAGES

243-247

Book

TITLE

New Experimental Modalities in the Control of Neoplasia

ISBN

978-1-4684-5244-0
978-1-4684-5242-6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4684-5242-6_18

DOI

http://dx.doi.org/10.1007/978-1-4684-5242-6_18

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047275929


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