Therapeutic Efficacy of Oxazaphosphorines by Immunomodulation View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1986

AUTHORS

R. Voegeli , J. Pohl , T. Reissmann , J. Stekar , P. Hilgard

ABSTRACT

Cyclophosphamide and a few related compounds of the class of oxazaphosphorines are widely used in the chemotherapy of malignant diseases. Their antitumour efficacy is based on their cytotoxic activity against quickly proliferating cells. Beside this, these agents are strong immunosuppressants and a particularly high sensitivity of antibody-producing, proliferating B cells was postulated (1). In contrast, it could be shown that cyclophosphamide in non-toxic doses enhanced delayed-type hypersensitivity reactions, which indicated a selective effect of cyclophosphamide on T cells (2,3). More... »

PAGES

243-247

Book

TITLE

New Experimental Modalities in the Control of Neoplasia

ISBN

978-1-4684-5244-0
978-1-4684-5242-6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4684-5242-6_18

DOI

http://dx.doi.org/10.1007/978-1-4684-5242-6_18

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047275929


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Department of Experimental Cancer Research, Asta-Werke AG Degussa Pharma Gruppe, D-4800\u00a0Bielefeld 14, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Voegeli", 
        "givenName": "R.", 
        "id": "sg:person.0633453775.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633453775.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Experimental Cancer Research, Asta-Werke AG Degussa Pharma Gruppe, D-4800\u00a0Bielefeld 14, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pohl", 
        "givenName": "J.", 
        "id": "sg:person.0750105001.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750105001.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Experimental Cancer Research, Asta-Werke AG Degussa Pharma Gruppe, D-4800\u00a0Bielefeld 14, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reissmann", 
        "givenName": "T.", 
        "id": "sg:person.01340535776.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340535776.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Experimental Cancer Research, Asta-Werke AG Degussa Pharma Gruppe, D-4800\u00a0Bielefeld 14, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stekar", 
        "givenName": "J.", 
        "id": "sg:person.064602232.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.064602232.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Experimental Cancer Research, Asta-Werke AG Degussa Pharma Gruppe, D-4800\u00a0Bielefeld 14, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hilgard", 
        "givenName": "P.", 
        "id": "sg:person.01023655171.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023655171.21"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00232352", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023463040", 
          "https://doi.org/10.1007/bf00232352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00232352", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023463040", 
          "https://doi.org/10.1007/bf00232352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00232352", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023463040", 
          "https://doi.org/10.1007/bf00232352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/271663a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041761092", 
          "https://doi.org/10.1038/271663a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/262077a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053098476", 
          "https://doi.org/10.1038/262077a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.141.3.697", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053425745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081749272", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082079384", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082102320", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1986", 
    "datePublishedReg": "1986-01-01", 
    "description": "Cyclophosphamide and a few related compounds of the class of oxazaphosphorines are widely used in the chemotherapy of malignant diseases. Their antitumour efficacy is based on their cytotoxic activity against quickly proliferating cells. Beside this, these agents are strong immunosuppressants and a particularly high sensitivity of antibody-producing, proliferating B cells was postulated (1). In contrast, it could be shown that cyclophosphamide in non-toxic doses enhanced delayed-type hypersensitivity reactions, which indicated a selective effect of cyclophosphamide on T cells (2,3).", 
    "editor": [
      {
        "familyName": "Chandra", 
        "givenName": "Prakash", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-1-4684-5242-6_18", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-1-4684-5244-0", 
        "978-1-4684-5242-6"
      ], 
      "name": "New Experimental Modalities in the Control of Neoplasia", 
      "type": "Book"
    }, 
    "name": "Therapeutic Efficacy of Oxazaphosphorines by Immunomodulation", 
    "pagination": "243-247", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-1-4684-5242-6_18"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e13552ceb2210380746361336591b511cb7ef3f576dbfe211ad44006b7ea7a73"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1047275929"
        ]
      }
    ], 
    "publisher": {
      "location": "Boston, MA", 
      "name": "Springer US", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-1-4684-5242-6_18", 
      "https://app.dimensions.ai/details/publication/pub.1047275929"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-15T22:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000272.jsonl", 
    "type": "Chapter", 
    "url": "http://link.springer.com/10.1007/978-1-4684-5242-6_18"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4684-5242-6_18'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4684-5242-6_18'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4684-5242-6_18'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4684-5242-6_18'


 

This table displays all metadata directly associated to this object as RDF triples.

121 TRIPLES      23 PREDICATES      34 URIs      20 LITERALS      8 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-1-4684-5242-6_18 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N4ea44118665849e5ab225455da856ae9
4 schema:citation sg:pub.10.1007/bf00232352
5 sg:pub.10.1038/262077a0
6 sg:pub.10.1038/271663a0
7 https://app.dimensions.ai/details/publication/pub.1081749272
8 https://app.dimensions.ai/details/publication/pub.1082079384
9 https://app.dimensions.ai/details/publication/pub.1082102320
10 https://doi.org/10.1084/jem.141.3.697
11 schema:datePublished 1986
12 schema:datePublishedReg 1986-01-01
13 schema:description Cyclophosphamide and a few related compounds of the class of oxazaphosphorines are widely used in the chemotherapy of malignant diseases. Their antitumour efficacy is based on their cytotoxic activity against quickly proliferating cells. Beside this, these agents are strong immunosuppressants and a particularly high sensitivity of antibody-producing, proliferating B cells was postulated (1). In contrast, it could be shown that cyclophosphamide in non-toxic doses enhanced delayed-type hypersensitivity reactions, which indicated a selective effect of cyclophosphamide on T cells (2,3).
14 schema:editor N5fe573a749c441c58a04667bae158087
15 schema:genre chapter
16 schema:inLanguage en
17 schema:isAccessibleForFree false
18 schema:isPartOf N815348bb18594b989953775fff39bb25
19 schema:name Therapeutic Efficacy of Oxazaphosphorines by Immunomodulation
20 schema:pagination 243-247
21 schema:productId N64d3daf776c74830be898ead5570b626
22 Na90761ff0f0c4ed8acfb96ed5bbce6c2
23 Nfb49d0955d284b73a6754466bff47058
24 schema:publisher N7ccba64e2847478f877fa6aab27a6369
25 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047275929
26 https://doi.org/10.1007/978-1-4684-5242-6_18
27 schema:sdDatePublished 2019-04-15T22:01
28 schema:sdLicense https://scigraph.springernature.com/explorer/license/
29 schema:sdPublisher N83bb4302dbe84a7c85f8130b0a28a60c
30 schema:url http://link.springer.com/10.1007/978-1-4684-5242-6_18
31 sgo:license sg:explorer/license/
32 sgo:sdDataset chapters
33 rdf:type schema:Chapter
34 N0eb61d8058744128a9bd85063cfc72ea rdf:first sg:person.01340535776.53
35 rdf:rest Nd586a7f74a5e45aeaa259477a1ce062a
36 N24482d4de74c457daf46a8a86e1a2735 schema:familyName Chandra
37 schema:givenName Prakash
38 rdf:type schema:Person
39 N4ea44118665849e5ab225455da856ae9 rdf:first sg:person.0633453775.54
40 rdf:rest Nad518ec12d48465fb2587f04caaef2e8
41 N50a8c77a3f2c43408df725ef79e2a893 schema:name Department of Experimental Cancer Research, Asta-Werke AG Degussa Pharma Gruppe, D-4800 Bielefeld 14, Germany
42 rdf:type schema:Organization
43 N5fe573a749c441c58a04667bae158087 rdf:first N24482d4de74c457daf46a8a86e1a2735
44 rdf:rest rdf:nil
45 N64d3daf776c74830be898ead5570b626 schema:name dimensions_id
46 schema:value pub.1047275929
47 rdf:type schema:PropertyValue
48 N7ccba64e2847478f877fa6aab27a6369 schema:location Boston, MA
49 schema:name Springer US
50 rdf:type schema:Organisation
51 N815348bb18594b989953775fff39bb25 schema:isbn 978-1-4684-5242-6
52 978-1-4684-5244-0
53 schema:name New Experimental Modalities in the Control of Neoplasia
54 rdf:type schema:Book
55 N83bb4302dbe84a7c85f8130b0a28a60c schema:name Springer Nature - SN SciGraph project
56 rdf:type schema:Organization
57 N85044b6e03e741e8bfa0fa4e1543ed84 rdf:first sg:person.01023655171.21
58 rdf:rest rdf:nil
59 N8b5595badca740a1acc364ac65306e79 schema:name Department of Experimental Cancer Research, Asta-Werke AG Degussa Pharma Gruppe, D-4800 Bielefeld 14, Germany
60 rdf:type schema:Organization
61 Na121f4aac33941beac5ed7408b867de1 schema:name Department of Experimental Cancer Research, Asta-Werke AG Degussa Pharma Gruppe, D-4800 Bielefeld 14, Germany
62 rdf:type schema:Organization
63 Na90761ff0f0c4ed8acfb96ed5bbce6c2 schema:name readcube_id
64 schema:value e13552ceb2210380746361336591b511cb7ef3f576dbfe211ad44006b7ea7a73
65 rdf:type schema:PropertyValue
66 Nad518ec12d48465fb2587f04caaef2e8 rdf:first sg:person.0750105001.98
67 rdf:rest N0eb61d8058744128a9bd85063cfc72ea
68 Nb5acdf6475cb475685bd3fa28bf4da77 schema:name Department of Experimental Cancer Research, Asta-Werke AG Degussa Pharma Gruppe, D-4800 Bielefeld 14, Germany
69 rdf:type schema:Organization
70 Nd586a7f74a5e45aeaa259477a1ce062a rdf:first sg:person.064602232.91
71 rdf:rest N85044b6e03e741e8bfa0fa4e1543ed84
72 Nec8ea09606a440a5ac93ed3807e5e699 schema:name Department of Experimental Cancer Research, Asta-Werke AG Degussa Pharma Gruppe, D-4800 Bielefeld 14, Germany
73 rdf:type schema:Organization
74 Nfb49d0955d284b73a6754466bff47058 schema:name doi
75 schema:value 10.1007/978-1-4684-5242-6_18
76 rdf:type schema:PropertyValue
77 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
78 schema:name Medical and Health Sciences
79 rdf:type schema:DefinedTerm
80 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
81 schema:name Oncology and Carcinogenesis
82 rdf:type schema:DefinedTerm
83 sg:person.01023655171.21 schema:affiliation Nec8ea09606a440a5ac93ed3807e5e699
84 schema:familyName Hilgard
85 schema:givenName P.
86 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023655171.21
87 rdf:type schema:Person
88 sg:person.01340535776.53 schema:affiliation N50a8c77a3f2c43408df725ef79e2a893
89 schema:familyName Reissmann
90 schema:givenName T.
91 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340535776.53
92 rdf:type schema:Person
93 sg:person.0633453775.54 schema:affiliation N8b5595badca740a1acc364ac65306e79
94 schema:familyName Voegeli
95 schema:givenName R.
96 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633453775.54
97 rdf:type schema:Person
98 sg:person.064602232.91 schema:affiliation Nb5acdf6475cb475685bd3fa28bf4da77
99 schema:familyName Stekar
100 schema:givenName J.
101 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.064602232.91
102 rdf:type schema:Person
103 sg:person.0750105001.98 schema:affiliation Na121f4aac33941beac5ed7408b867de1
104 schema:familyName Pohl
105 schema:givenName J.
106 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750105001.98
107 rdf:type schema:Person
108 sg:pub.10.1007/bf00232352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023463040
109 https://doi.org/10.1007/bf00232352
110 rdf:type schema:CreativeWork
111 sg:pub.10.1038/262077a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053098476
112 https://doi.org/10.1038/262077a0
113 rdf:type schema:CreativeWork
114 sg:pub.10.1038/271663a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041761092
115 https://doi.org/10.1038/271663a0
116 rdf:type schema:CreativeWork
117 https://app.dimensions.ai/details/publication/pub.1081749272 schema:CreativeWork
118 https://app.dimensions.ai/details/publication/pub.1082079384 schema:CreativeWork
119 https://app.dimensions.ai/details/publication/pub.1082102320 schema:CreativeWork
120 https://doi.org/10.1084/jem.141.3.697 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053425745
121 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...