Immunological Studies on Lysosomal Sphingomyelinase: Immunization Procedures, Properties of Polyclonal and Monoclonal Antibodies Obtained and Effect of Triton X-100 on ... View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1986

AUTHORS

E. J. M. Al , G. Weitz , K. Sandhoff , J. A. Barranger , J. H. M. Hilgers , J. M. Tager , A. W. Schram

ABSTRACT

Sphingomyelinase hydrolyses sphingomyelin to ceramide and phosphoryl choline. In tissues from patients suffering from Niemann-Pick disease type A and B this lysosomal, membrane-associated enzyme is deficient and sphingomyelin accumulates1. In tissues from patients with Niemann-Pick disease type C, sphingomyelin also accumulates but sphingomyelinase is not deficient1.

PAGES

279-283

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4684-5212-9_39

DOI

http://dx.doi.org/10.1007/978-1-4684-5212-9_39

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020795043


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