Protein Phosphorylations As a Mode of Insulin Action View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1985

AUTHORS

Joseph Avruch , Raphael A. Nemenoff , Mark Pierce , Yan C. Kwok , Perry J. Blackshear

ABSTRACT

Within minutes after the interaction of insulin with its receptor, marked changes occur in the metabolic pattern of the cell. In classic target tissues, insulin inhibits catabolic pathways (e.g., glycogenolysis and lipolysis), concurrently activating anabolic pathways (such as glycogen synthesis and de novo fatty acid synthesis). These effects are due to alterations in the activity of a variety of intracellular enzymes and transcellular transport processes. Over a longer period of time, insulin also participates in regulating the expression of specific genes and, in certain cell types, insulin modulates cell division and growth. More... »

PAGES

263-296

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4684-4874-0_16

DOI

http://dx.doi.org/10.1007/978-1-4684-4874-0_16

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002055735


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Howard Hughes Medical Institute Laboratory, Harvard Medical School, Boston, Massachusetts, USA", 
            "Diabetes Unit and Medical Services, Massachusetts General Hospital, Boston, Massachusetts, USA", 
            "Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Avruch", 
        "givenName": "Joseph", 
        "id": "sg:person.01074100404.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074100404.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Howard Hughes Medical Institute Laboratory, Harvard Medical School, Boston, Massachusetts, USA", 
            "Diabetes Unit and Medical Services, Massachusetts General Hospital, Boston, Massachusetts, USA", 
            "Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nemenoff", 
        "givenName": "Raphael A.", 
        "id": "sg:person.07420547645.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07420547645.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Howard Hughes Medical Institute Laboratory, Harvard Medical School, Boston, Massachusetts, USA", 
            "Diabetes Unit and Medical Services, Massachusetts General Hospital, Boston, Massachusetts, USA", 
            "Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pierce", 
        "givenName": "Mark", 
        "id": "sg:person.01115113377.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115113377.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Howard Hughes Medical Institute Laboratory, Harvard Medical School, Boston, Massachusetts, USA", 
            "Diabetes Unit and Medical Services, Massachusetts General Hospital, Boston, Massachusetts, USA", 
            "Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kwok", 
        "givenName": "Yan C.", 
        "id": "sg:person.01210557435.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210557435.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Howard Hughes Medical Institute Laboratory, Harvard Medical School, Boston, Massachusetts, USA", 
            "Diabetes Unit and Medical Services, Massachusetts General Hospital, Boston, Massachusetts, USA", 
            "Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blackshear", 
        "givenName": "Perry J.", 
        "id": "sg:person.013315335037.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013315335037.56"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1985", 
    "datePublishedReg": "1985-01-01", 
    "description": "Within minutes after the interaction of insulin with its receptor, marked changes occur in the metabolic pattern of the cell. In classic target tissues, insulin inhibits catabolic pathways (e.g., glycogenolysis and lipolysis), concurrently activating anabolic pathways (such as glycogen synthesis and de novo fatty acid synthesis). These effects are due to alterations in the activity of a variety of intracellular enzymes and transcellular transport processes. Over a longer period of time, insulin also participates in regulating the expression of specific genes and, in certain cell types, insulin modulates cell division and growth.", 
    "editor": [
      {
        "familyName": "Czech", 
        "givenName": "Michael P.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-1-4684-4874-0_16", 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-1-4684-4876-4", 
        "978-1-4684-4874-0"
      ], 
      "name": "Molecular Basis of Insulin Action", 
      "type": "Book"
    }, 
    "keywords": [
      "modulates cell division", 
      "certain cell types", 
      "protein phosphorylation", 
      "cell division", 
      "specific genes", 
      "anabolic pathways", 
      "interaction of insulin", 
      "cell types", 
      "classic target tissues", 
      "intracellular enzymes", 
      "insulin inhibits", 
      "transcellular transport processes", 
      "insulin action", 
      "pathway", 
      "target tissues", 
      "metabolic patterns", 
      "insulin", 
      "genes", 
      "phosphorylation", 
      "enzyme", 
      "expression", 
      "cells", 
      "inhibits", 
      "transport processes", 
      "division", 
      "receptors", 
      "growth", 
      "tissue", 
      "alterations", 
      "long period", 
      "minutes", 
      "interaction", 
      "activity", 
      "patterns", 
      "variety", 
      "period", 
      "action", 
      "effect", 
      "changes", 
      "types", 
      "process", 
      "time", 
      "mode"
    ], 
    "name": "Protein Phosphorylations As a Mode of Insulin Action", 
    "pagination": "263-296", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1002055735"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-1-4684-4874-0_16"
        ]
      }
    ], 
    "publisher": {
      "name": "Springer Nature", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-1-4684-4874-0_16", 
      "https://app.dimensions.ai/details/publication/pub.1002055735"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2022-09-02T16:16", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/chapter/chapter_382.jsonl", 
    "type": "Chapter", 
    "url": "https://doi.org/10.1007/978-1-4684-4874-0_16"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4684-4874-0_16'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4684-4874-0_16'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4684-4874-0_16'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4684-4874-0_16'


 

This table displays all metadata directly associated to this object as RDF triples.

140 TRIPLES      22 PREDICATES      70 URIs      61 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-1-4684-4874-0_16 schema:about anzsrc-for:06
2 anzsrc-for:0601
3 anzsrc-for:11
4 anzsrc-for:1103
5 schema:author N8f49a131aeba49fca45188587572da1f
6 schema:datePublished 1985
7 schema:datePublishedReg 1985-01-01
8 schema:description Within minutes after the interaction of insulin with its receptor, marked changes occur in the metabolic pattern of the cell. In classic target tissues, insulin inhibits catabolic pathways (e.g., glycogenolysis and lipolysis), concurrently activating anabolic pathways (such as glycogen synthesis and de novo fatty acid synthesis). These effects are due to alterations in the activity of a variety of intracellular enzymes and transcellular transport processes. Over a longer period of time, insulin also participates in regulating the expression of specific genes and, in certain cell types, insulin modulates cell division and growth.
9 schema:editor N40a3a81bf2804314b903fe42468f65de
10 schema:genre chapter
11 schema:isAccessibleForFree false
12 schema:isPartOf Nb0eae318617442de855d7ee09da513a9
13 schema:keywords action
14 activity
15 alterations
16 anabolic pathways
17 cell division
18 cell types
19 cells
20 certain cell types
21 changes
22 classic target tissues
23 division
24 effect
25 enzyme
26 expression
27 genes
28 growth
29 inhibits
30 insulin
31 insulin action
32 insulin inhibits
33 interaction
34 interaction of insulin
35 intracellular enzymes
36 long period
37 metabolic patterns
38 minutes
39 mode
40 modulates cell division
41 pathway
42 patterns
43 period
44 phosphorylation
45 process
46 protein phosphorylation
47 receptors
48 specific genes
49 target tissues
50 time
51 tissue
52 transcellular transport processes
53 transport processes
54 types
55 variety
56 schema:name Protein Phosphorylations As a Mode of Insulin Action
57 schema:pagination 263-296
58 schema:productId N55606aeaecbf415594340f15cb95313f
59 Nba2d546c6835437fbc8fb94a506e3f9d
60 schema:publisher N5b5882ebd6b64710b56208c0b4690a1b
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002055735
62 https://doi.org/10.1007/978-1-4684-4874-0_16
63 schema:sdDatePublished 2022-09-02T16:16
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher Nda0bc81c34e44812b4519c11dee2d173
66 schema:url https://doi.org/10.1007/978-1-4684-4874-0_16
67 sgo:license sg:explorer/license/
68 sgo:sdDataset chapters
69 rdf:type schema:Chapter
70 N062356ee59064faa989dbde9e92c0701 rdf:first sg:person.01210557435.97
71 rdf:rest N752a29fd11724b7a95c336cd21f2b037
72 N40a3a81bf2804314b903fe42468f65de rdf:first Nebf9fd865b134a10bc2dfedff8a74fc0
73 rdf:rest rdf:nil
74 N55606aeaecbf415594340f15cb95313f schema:name doi
75 schema:value 10.1007/978-1-4684-4874-0_16
76 rdf:type schema:PropertyValue
77 N5b5882ebd6b64710b56208c0b4690a1b schema:name Springer Nature
78 rdf:type schema:Organisation
79 N752a29fd11724b7a95c336cd21f2b037 rdf:first sg:person.013315335037.56
80 rdf:rest rdf:nil
81 N8f49a131aeba49fca45188587572da1f rdf:first sg:person.01074100404.77
82 rdf:rest N9e659edd050449c5943635655ba296a6
83 N96f6911e51dd40889ded54bb4b673a1e rdf:first sg:person.01115113377.85
84 rdf:rest N062356ee59064faa989dbde9e92c0701
85 N9e659edd050449c5943635655ba296a6 rdf:first sg:person.07420547645.99
86 rdf:rest N96f6911e51dd40889ded54bb4b673a1e
87 Nb0eae318617442de855d7ee09da513a9 schema:isbn 978-1-4684-4874-0
88 978-1-4684-4876-4
89 schema:name Molecular Basis of Insulin Action
90 rdf:type schema:Book
91 Nba2d546c6835437fbc8fb94a506e3f9d schema:name dimensions_id
92 schema:value pub.1002055735
93 rdf:type schema:PropertyValue
94 Nda0bc81c34e44812b4519c11dee2d173 schema:name Springer Nature - SN SciGraph project
95 rdf:type schema:Organization
96 Nebf9fd865b134a10bc2dfedff8a74fc0 schema:familyName Czech
97 schema:givenName Michael P.
98 rdf:type schema:Person
99 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
100 schema:name Biological Sciences
101 rdf:type schema:DefinedTerm
102 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
103 schema:name Biochemistry and Cell Biology
104 rdf:type schema:DefinedTerm
105 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
106 schema:name Medical and Health Sciences
107 rdf:type schema:DefinedTerm
108 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
109 schema:name Clinical Sciences
110 rdf:type schema:DefinedTerm
111 sg:person.01074100404.77 schema:affiliation grid-institutes:grid.38142.3c
112 schema:familyName Avruch
113 schema:givenName Joseph
114 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074100404.77
115 rdf:type schema:Person
116 sg:person.01115113377.85 schema:affiliation grid-institutes:grid.38142.3c
117 schema:familyName Pierce
118 schema:givenName Mark
119 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115113377.85
120 rdf:type schema:Person
121 sg:person.01210557435.97 schema:affiliation grid-institutes:grid.38142.3c
122 schema:familyName Kwok
123 schema:givenName Yan C.
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210557435.97
125 rdf:type schema:Person
126 sg:person.013315335037.56 schema:affiliation grid-institutes:grid.38142.3c
127 schema:familyName Blackshear
128 schema:givenName Perry J.
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013315335037.56
130 rdf:type schema:Person
131 sg:person.07420547645.99 schema:affiliation grid-institutes:grid.38142.3c
132 schema:familyName Nemenoff
133 schema:givenName Raphael A.
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07420547645.99
135 rdf:type schema:Person
136 grid-institutes:grid.38142.3c schema:alternateName Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
137 schema:name Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
138 Diabetes Unit and Medical Services, Massachusetts General Hospital, Boston, Massachusetts, USA
139 Howard Hughes Medical Institute Laboratory, Harvard Medical School, Boston, Massachusetts, USA
140 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...