Allosteric Interactions in Receptor Binding Studies View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1984

AUTHORS

N. J. M. Birdsall , E. C. Hulme , J. Stockton , M. J. Zigmond

ABSTRACT

Receptor binding studies can not only detect the competitive interaction of drugs with the binding site for a radiolabeled drug, but also render it possible to monitor the binding of ligands to secondary sites which are allosterically linked to the primary binding site. These modulatory ligands can produce their effects by interacting with a second site on the receptor protein or on other proteins which interact specifically with the receptor. It is possible to obtain information about receptor-effector coupling mechanisms as well as to detect binding sites for drugs which could have novel pharmacological profiles. More... »

PAGES

481-486

References to SciGraph publications

Book

TITLE

Investigation of Membrane-Located Receptors

ISBN

978-1-4684-4633-3
978-1-4684-4631-9

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4684-4631-9_55

DOI

http://dx.doi.org/10.1007/978-1-4684-4631-9_55

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041045685


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