Accelerated Aging in Down’s Syndrome: The Concept of Hierarchical Homeostasis in Relation to Local and Global Failure View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1983

AUTHORS

Roy L. Walford , Faramarz Naeim , Kathleen Y. Hall , C. F. Tam , Richard A. Gatti , Michael A. Medici

ABSTRACT

A number of diseases are known to manifest various features of accelerated aging, including progeria, Werner’s syndrome, most of the chromosomal instability syndromes (Gatti and Walford, 1981), various other maladies (Martin, 1978) and — reflecting our own particular interests — systemic lypus erythematosus (SLE) (Barnett et al., 1981) and Down’s syndrome (DS) (Walford et al., 1981). Table 1 lists a number of the non-immune hallmarks of aging as seen normally and in various diseases characterized in part by accelerated aging. DS demonstrates many features of accelerated aging: premature greying of hair, degenerative vascular disease, amyloidosis, hypogonadism, senile dementia of the Alzheimer’s type, immune dysfunction, possibly an increased susceptibility to diabetes, and decreased replicative capacity of fibroblasts, among others. More... »

PAGES

399-417

Book

TITLE

Immunoregulation

ISBN

978-1-4684-4549-7
978-1-4684-4547-3

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4684-4547-3_25

DOI

http://dx.doi.org/10.1007/978-1-4684-4547-3_25

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038346175


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