Antibody-Mediated Targeting of Liposomes View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1982

AUTHORS

John N. Weinstein , Lee D. Leserman , Pierre A. Henkart , Robert Blumenthal

ABSTRACT

We have studied a number of permutations on the use of antibody and antigen for targeting liposomes in vitro. Our first strategy was to make liposomes with lipid bearing the dinitrophenyl (DNP) hapten. These liposomes bound specifically to cells in three experimental configurations: (i) with TNP-modified human peripheral blood lymphocytes as targets and sheep IgG anti-TNP as cross-linking agent; (ii) with murine myeloma MOPC 315 cells (which bear an IgA with high affinity for nitrophenyl haptens) as target, using endogeneous surface immunoglobulin on the cells as a point of attachment; (iii) with Fc-receptor bearing cells as targets and rabbit anti-TNP as an opsonizing agent. We monitored the interactions by encapsulating carboxyfluorescein and/or methotrexate in the liposomes, and in some experiments by incorporating 14C-dipalmitoyl phosphatidylcholine or a fluorescent marker in the lipid. In each study large numbers of liposomes could be bound specifically to the target cells, but they were internalized in significant numbers only in (iii) when cells capable of Fc-mediated endocytosis were used. The most striking internalization was found with the mouse macrophage line P388D1. Encapsulated methotrexate had a several-fold greater effect on the metabolism of P388D1 (as assayed by 3H-deoxyuridine uptake) than did an equivalent amount of methotrexate free in solution. This finding indicated that an appropriately chosen drug can escape the phagosomal system to exert its effect in the cytoplasm. More... »

PAGES

185-202

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4684-4241-0_11

DOI

http://dx.doi.org/10.1007/978-1-4684-4241-0_11

DIMENSIONS

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