Hyperfiltration as a Major Causative Factor in Initiation and Progression of Glomerulosclerosis View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1982

AUTHORS

Thomas H. Hostetter , Helmut G. Rennke , Barry M. Brenner

ABSTRACT

The augmentation of single-nephron glomerular filtration rate (SNGFR) that follows loss of functioning renal mass is generally regarded as a beneficial adaptation in the sense that total filtration by the remnant kidney falls less than would be the case had this augmentation not occurred. However, several lines of evidence have been developed that, when taken together, suggest that single-nephron hyperfiltration may have maladaptive and eventually injurious consequences. For nearly 50 years it has been recognized that removal of approximately three fourths or more of the renal mass in the rat, either by surgical resection, infarction, or a combination of these maneuvers, results in a syndrome of progressive azotemia, proteinuria, and eventual glomerular sclerosis.l–3 More... »

PAGES

45-54

Book

TITLE

Prevention of Kidney Disease and Long-Term Survival

ISBN

978-1-4684-4201-4
978-1-4684-4199-4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4684-4199-4_5

DOI

http://dx.doi.org/10.1007/978-1-4684-4199-4_5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052208338


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