On Network Theory and H-2 Restriction View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1980

AUTHORS

Geoffrey W. Hoffmann

ABSTRACT

The network hypothesis of Jerne (1974a,b, 1976) is based on the fact that the V (variable) regions of antibody molecules can function as antigens. Such antibodies can therefore stimulate and/or suppress responses of cells that have receptors which specifically recognize these V regions. One network model that incorporates this postulate is the “plus-minus network theory” (Hoffmann, 1975, 1978). In this paper a more extensive review of the data relevant to the theory is presented, and a number of phenomena are discussed within the framework of the theory that were not previously treated. These phenomena include the subclasses of T cells and H-2 restriction. More... »

PAGES

185-226

Book

TITLE

Contemporary Topics in Immunobiology

ISBN

978-1-4684-3703-4
978-1-4684-3701-0

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4684-3701-0_6

DOI

http://dx.doi.org/10.1007/978-1-4684-3701-0_6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014960402


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Departments of Physics Microbiology, University of British Columbia, V6T 1W5, Vancouver, B.C., Canada", 
          "id": "http://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Basel Institute for Immunology, CH-4005, Basel, Switzerland", 
            "Departments of Physics Microbiology, University of British Columbia, V6T 1W5, Vancouver, B.C., Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hoffmann", 
        "givenName": "Geoffrey W.", 
        "id": "sg:person.01217305103.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217305103.87"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1980", 
    "datePublishedReg": "1980-01-01", 
    "description": "The network hypothesis of Jerne (1974a,b, 1976) is based on the fact that the V (variable) regions of antibody molecules can function as antigens. Such antibodies can therefore stimulate and/or suppress responses of cells that have receptors which specifically recognize these V regions. One network model that incorporates this postulate is the \u201cplus-minus network theory\u201d (Hoffmann, 1975, 1978). In this paper a more extensive review of the data relevant to the theory is presented, and a number of phenomena are discussed within the framework of the theory that were not previously treated. These phenomena include the subclasses of T cells and H-2 restriction.", 
    "editor": [
      {
        "familyName": "Warner", 
        "givenName": "Noel L.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-1-4684-3701-0_6", 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-1-4684-3703-4", 
        "978-1-4684-3701-0"
      ], 
      "name": "Contemporary Topics in Immunobiology", 
      "type": "Book"
    }, 
    "keywords": [
      "such antibodies", 
      "network theory", 
      "T cells", 
      "suppress responses", 
      "number of phenomena", 
      "network model", 
      "theory", 
      "antibody molecules", 
      "cells", 
      "antigen", 
      "antibodies", 
      "network hypothesis", 
      "receptors", 
      "extensive review", 
      "review", 
      "Jerne", 
      "response", 
      "restriction", 
      "phenomenon", 
      "Plus", 
      "subclasses", 
      "hypothesis", 
      "model", 
      "data", 
      "framework", 
      "region", 
      "postulates", 
      "number", 
      "molecules", 
      "fact", 
      "paper"
    ], 
    "name": "On Network Theory and H-2 Restriction", 
    "pagination": "185-226", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1014960402"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-1-4684-3701-0_6"
        ]
      }
    ], 
    "publisher": {
      "name": "Springer Nature", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-1-4684-3701-0_6", 
      "https://app.dimensions.ai/details/publication/pub.1014960402"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2022-12-01T06:47", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/chapter/chapter_143.jsonl", 
    "type": "Chapter", 
    "url": "https://doi.org/10.1007/978-1-4684-3701-0_6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4684-3701-0_6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4684-3701-0_6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4684-3701-0_6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4684-3701-0_6'


 

This table displays all metadata directly associated to this object as RDF triples.

91 TRIPLES      22 PREDICATES      56 URIs      49 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-1-4684-3701-0_6 schema:about anzsrc-for:11
2 anzsrc-for:1107
3 schema:author N8f1f13e9fe934bae9ffa7068658afa7b
4 schema:datePublished 1980
5 schema:datePublishedReg 1980-01-01
6 schema:description The network hypothesis of Jerne (1974a,b, 1976) is based on the fact that the V (variable) regions of antibody molecules can function as antigens. Such antibodies can therefore stimulate and/or suppress responses of cells that have receptors which specifically recognize these V regions. One network model that incorporates this postulate is the “plus-minus network theory” (Hoffmann, 1975, 1978). In this paper a more extensive review of the data relevant to the theory is presented, and a number of phenomena are discussed within the framework of the theory that were not previously treated. These phenomena include the subclasses of T cells and H-2 restriction.
7 schema:editor Nfa0dda9bbd2d49bfbf34fc935b110dde
8 schema:genre chapter
9 schema:isAccessibleForFree false
10 schema:isPartOf Ncaf5ac49041d48c4b1d6c319ed5a0bba
11 schema:keywords Jerne
12 Plus
13 T cells
14 antibodies
15 antibody molecules
16 antigen
17 cells
18 data
19 extensive review
20 fact
21 framework
22 hypothesis
23 model
24 molecules
25 network hypothesis
26 network model
27 network theory
28 number
29 number of phenomena
30 paper
31 phenomenon
32 postulates
33 receptors
34 region
35 response
36 restriction
37 review
38 subclasses
39 such antibodies
40 suppress responses
41 theory
42 schema:name On Network Theory and H-2 Restriction
43 schema:pagination 185-226
44 schema:productId Nad3c30f546b44bc9bbb2c7cad66d7a2c
45 Ndb110d22686f4fe5b66b4d2d88ef8381
46 schema:publisher Nffb94b3af29243e6b7e95392e2bbcd4b
47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014960402
48 https://doi.org/10.1007/978-1-4684-3701-0_6
49 schema:sdDatePublished 2022-12-01T06:47
50 schema:sdLicense https://scigraph.springernature.com/explorer/license/
51 schema:sdPublisher Ne4b445f408004229a655bb1469ab5fc4
52 schema:url https://doi.org/10.1007/978-1-4684-3701-0_6
53 sgo:license sg:explorer/license/
54 sgo:sdDataset chapters
55 rdf:type schema:Chapter
56 N8f1f13e9fe934bae9ffa7068658afa7b rdf:first sg:person.01217305103.87
57 rdf:rest rdf:nil
58 Nad3c30f546b44bc9bbb2c7cad66d7a2c schema:name dimensions_id
59 schema:value pub.1014960402
60 rdf:type schema:PropertyValue
61 Nc99261870a0249f1b2d943bc0f6f13c9 schema:familyName Warner
62 schema:givenName Noel L.
63 rdf:type schema:Person
64 Ncaf5ac49041d48c4b1d6c319ed5a0bba schema:isbn 978-1-4684-3701-0
65 978-1-4684-3703-4
66 schema:name Contemporary Topics in Immunobiology
67 rdf:type schema:Book
68 Ndb110d22686f4fe5b66b4d2d88ef8381 schema:name doi
69 schema:value 10.1007/978-1-4684-3701-0_6
70 rdf:type schema:PropertyValue
71 Ne4b445f408004229a655bb1469ab5fc4 schema:name Springer Nature - SN SciGraph project
72 rdf:type schema:Organization
73 Nfa0dda9bbd2d49bfbf34fc935b110dde rdf:first Nc99261870a0249f1b2d943bc0f6f13c9
74 rdf:rest rdf:nil
75 Nffb94b3af29243e6b7e95392e2bbcd4b schema:name Springer Nature
76 rdf:type schema:Organisation
77 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
78 schema:name Medical and Health Sciences
79 rdf:type schema:DefinedTerm
80 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
81 schema:name Immunology
82 rdf:type schema:DefinedTerm
83 sg:person.01217305103.87 schema:affiliation grid-institutes:grid.17091.3e
84 schema:familyName Hoffmann
85 schema:givenName Geoffrey W.
86 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217305103.87
87 rdf:type schema:Person
88 grid-institutes:grid.17091.3e schema:alternateName Departments of Physics Microbiology, University of British Columbia, V6T 1W5, Vancouver, B.C., Canada
89 schema:name Basel Institute for Immunology, CH-4005, Basel, Switzerland
90 Departments of Physics Microbiology, University of British Columbia, V6T 1W5, Vancouver, B.C., Canada
91 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...