On Network Theory and H-2 Restriction View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1980

AUTHORS

Geoffrey W. Hoffmann

ABSTRACT

The network hypothesis of Jerne (1974a,b, 1976) is based on the fact that the V (variable) regions of antibody molecules can function as antigens. Such antibodies can therefore stimulate and/or suppress responses of cells that have receptors which specifically recognize these V regions. One network model that incorporates this postulate is the “plus-minus network theory” (Hoffmann, 1975, 1978). In this paper a more extensive review of the data relevant to the theory is presented, and a number of phenomena are discussed within the framework of the theory that were not previously treated. These phenomena include the subclasses of T cells and H-2 restriction. More... »

PAGES

185-226

Book

TITLE

Contemporary Topics in Immunobiology

ISBN

978-1-4684-3703-4
978-1-4684-3701-0

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4684-3701-0_6

DOI

http://dx.doi.org/10.1007/978-1-4684-3701-0_6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014960402


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