The Use of Thermosensitive Mutants of E.coli in the Analysis of Cell Division View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1971

AUTHORS

Y. Hirota , M. Ricard , B. Shapiro

ABSTRACT

A series of temperature conditional mutants of E.coli K12 which are defective in different aspects of cell division were isolated. Some of these had thermosensitive mutations in DNA synthesis, either in the initiation of DNA synthesis or the elongation of DNA chain, DNA segregation and septation.Characterization of the biochemical lesions and the genetic analysis of the mutations were carried out in some mutants defective in DNA synthesis. In correlation with the alteration in DNA synthesis, several lines of evidence indicate an alteration in the structure of the cell membrane. The available results lead one to visualize the replication machinery as a complex structure which is integrated into the membrane.A model for the role of the membrane in the cell division process and some predictions of the model are presented. More... »

PAGES

13-31

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4684-3330-2_5

DOI

http://dx.doi.org/10.1007/978-1-4684-3330-2_5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030764558


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