Genetic Regulation of Macrophage Functions View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1976

AUTHORS

D. Mouton , Y. Bouthillier , A. M. Heumann , C. Stiffel , G. Biozzi

ABSTRACT

Macrophages are characterized by a high capacity of phagocytosis of foreign particles. The engulfed material is then submitted to the rich enzyme equipment contained in their phagosomes. These cells have, thus, a crucial role in both non-specific and specific immunity. Phagocytosis and bactericidal power are the bases of non-specific defence, while uptake and processing of antigens are the first steps of the complex cell interactions constituting the specific immune responses. The two mechanisms may operate synergically since, for example, opsonins specific antibodies increase the rate of bacterial phagocytosis. Furthermore, other mediators, such as MIF, specifically released by lymphocytes, modify different macrophage functions. More... »

PAGES

225-236

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4684-3297-8_19

DOI

http://dx.doi.org/10.1007/978-1-4684-3297-8_19

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017698811

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/793348


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