The Source of Cells within Different Areas of Lymph Nodes Draining the Site of Primary Stimulation with a Contact Sensitizing ... View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1969

AUTHORS

Delphine M. V. Parrott , Maria A. B. de Sousa

ABSTRACT

The cortex of the mouse lymph node can be clearly divided into two areas, a peripheral area of primary nodules, which are round, packed aggregations of lymphocytes, and midcortical area containing lymphocytes spread as a loose, wide sheet rather than as nodular aggregations like the periphery. The latter area of the lymph node, the paracortical area of Oort and Turk [1], has been called thymus- dependent for the following reasons: The depletion of lymphocytes seen in the lymph nodes of mice thymectomized at birth is primarily restricted to the paracortical area, leaving the primary nodules and medullary area relatively unaffected [2]. Autoradiographic studies have demonstrated that thymus cells, whether labeled in vitro with 3H-adenosine and injected intravenously [2] or emigrating from a thymus graft labeled in vivo with 3H-thymidine [3] or from a thymus labeled in situ with 3H-thymidine [4], localize almost exclusively in the thymus-dependent areas of lymph nodes, often close to the postcapillary venules. More... »

PAGES

293-307

Book

TITLE

Lymphatic Tissue and Germinal Centers in Immune Response

ISBN

978-1-4684-3194-0
978-1-4684-3192-6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4684-3192-6_31

DOI

http://dx.doi.org/10.1007/978-1-4684-3192-6_31

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030327036


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