Toxicity and Antitumor Effect of 5-Fluorouracil and its Rescue by Uridine View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

1986

AUTHORS

G. J. Peters , J. van Dijk , C. van Groeningen , E. J. Laurensse , A. Leyva , J. Lankelma , H. M. Pinedo

ABSTRACT

The pyrimidine analog 5-fluorouracil (5FU) has been used in the treatment against several solid carcinomas, mainly of the colon, for several decades (1). However, overall response rate is only about 20%, while gastrointestinal and myeloid toxicity are dose-limiting (1). Research on 5FU has been directed towards enhancing 5FU anabolism by combination with e.g. methotrexate (2) or thymidine (3) and towards the development of several analogs of 5FU. One recent analog, Doxifluridine (5′-deoxy-5-fluorouridine, 5’dFUR) showed an improved therapeutic index against a broad range of murine and rat tumors (4,5) and therapeutic activity in human advanced rectosigmoid adenocarcinoma (6). More... »

PAGES

121-8

References to SciGraph publications

  • 1982-04. Uridine rescue from the lethal toxicity of 5-fluorouracil in mice in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-4684-1248-2_19

    DOI

    http://dx.doi.org/10.1007/978-1-4684-1248-2_19

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/2945404


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