Inhibition of Tumor Promotion by DL-α-Difluoromethylornithine, A Specific Irreversible Inhibitor of Ornithine Decarboxylase View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1990

AUTHORS

Ajit K. Verma

ABSTRACT

Although a chemoprevention program can be targeted for intervention at any one of the steps (initiation, promotion, and progression) involved in the induction of cancer, interference with the promotion stage of carcinogenesis appears to be most appropriate and practical. The rationale behind this comes from the facts that promotion of tumor formation requires a repeated and prolonged exposure to a promoter and that tumor promotion is reversible, at least in the early stages. In contrast, initiation can be accomplished by a single exposure to a sufficiently small dose of a carcinogen, and this step is rapid and irreversible (3,36,41). More... »

PAGES

195-204

Book

TITLE

Antimutagenesis and Anticarcinogenesis Mechanisms II

ISBN

978-1-4615-9563-2
978-1-4615-9561-8

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-9561-8_16

DOI

http://dx.doi.org/10.1007/978-1-4615-9561-8_16

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025007478


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