The Role of Human RAS Proto-Oncogenes in Cancer View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1985

AUTHORS

Steven R. Tronick , Alessandra Eva , Shiv Srivastava , Matthias Kraus , Yasuhito Yuasa , Stuart Aaronson

ABSTRACT

Acute transforming retroviruses have arisen in nature by recombination of replication competent type C retroviruses with evolutionarily well conserved cellular genes, termed proto-oncogenes. When incorporated by the retrovirus, such transduced cellular (onc) sequences confer properties essential for the induction and maintenance of virus induced transformation (Weiss et al., 1982; Duesberg, 1983; Bishop, 1983). Recent studies have provided evidence that proto-oncogenes can be activated as oncogenes by other mechanisms as well. Of particular importance in this regard is accumulating evidence that proto-oncogenes may be frequent targets for genetic alterations involved in neoplastic processes affecting human cells. In the present review, we describe investigations of a family of proto-oncogenes, designated ras, which has been strongly implicated in processes leading to malignancy in a wide variety of human cell types. More... »

PAGES

225-233

Book

TITLE

Epidemiology and Quantitation of Environmental Risk in Humans from Radiation and Other Agents

ISBN

978-1-4615-9447-5
978-1-4615-9445-1

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-9445-1_15

DOI

http://dx.doi.org/10.1007/978-1-4615-9445-1_15

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040609749


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