Fibrinogen and Platelet Function View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1985

AUTHORS

Gérard A. Marguerie , Mark. H. Ginsberg , Edward F. Plow

ABSTRACT

Formation of efficient plugs at sites of injury of a vessel wall is contingent upon modifications of the adhesive properties of the membrane of platelets. These alterations are generally accomplished via a multi steps mechanism encompassing: 1) adhesion and spreading of the cells to the subendothelial matrix; 2) activation of the platelet by specific agonists; and 3) interaction of the activated platelet with cofactors which modify the adhesive properties of the cell, to form aggregates. A number of biochemical events have been associated with this phenomenon. This includes calcium distribution, prostaglandin synthesis, actin polymerization, microtubules disassembly, and changes in adenylate cyclase activity. While these reactions have been identified their sequence and interrelationship in the transition reaction between a circulating and an aggregating platelet have yet to be delineated. It is well established, however that a specific stimulus and an exogenous cofactor with adhesive properties are necessary for aggregation to occur. Early studies on patients with congenital afibrinogenemia have provided evidences that fibrinogen fulfills the role of essential cofactor in this reaction. Platelets from these patients fail to aggregate or aggregate weakly in response to ADP or epinephrine and normal aggregation is restored upon addition of fibrinogen in the plasma of these patients. More... »

PAGES

41-54

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4615-9442-0_4

DOI

http://dx.doi.org/10.1007/978-1-4615-9442-0_4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010171861

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3010672


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